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POD EXAM 3 > Cancer Dasgupta > Flashcards

Cancer Dasgupta Flashcards

1
Q

MOPP

A

Hodgkins disease

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2
Q

ABVD

A

Hodgkins disease

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3
Q

CHOP

A

Non-hodgkins

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4
Q

CMF

A

Breast

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5
Q

CAF

A

Breast

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6
Q

PACE

A

Small cell lung cancer

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7
Q

VIP

A

Germ Cell

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8
Q

BIP

A

Cervical

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9
Q

M_BACOD

A

Lymphomas

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10
Q

BEP

A

Ovarian

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11
Q

CVD

A

Pheochromocytoma

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12
Q

PEB

A

testicular

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13
Q

What are problems with cancer chemotherapy?

A

dose-limiting toxicity

resistance to chemo

glycoprotein pumps

2nd cancers

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14
Q

MOA of alkylating agents?

A

block DNA replication and transcription by adding a methyl group to guanine residue on 2 different spots

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15
Q

Are alkylating agents CCS or CCNS?

A

CCNS

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16
Q

What is special about Mechlorethamine?

A

It is not excreted

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17
Q

What is Mechlorethamine used for ?

A

Hodgkins disease (stage III and IV) in MOPP

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18
Q

What is special about Cyclophosphamide?

A

Must be activated by cytochrome P450 in liver

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19
Q

What is the side effect of Cyclophosphamide?

A

Hemorrhagic cystitis

SIADH (water intoxication) (democyclin manages)

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20
Q

What is Cyclophosphamide used for?

A

Burkitts lymphoma
Acute lymphotic leukemia
Other lymphoma and leukemia

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21
Q

What is the side effect of chlorambucil?

A

Hepatotoxicity

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22
Q

What is chlorambucil used for?

A

Chronic lymphocytic leukemia (CLL)

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23
Q

What do you use the lower hemmoragic cystis produced by acrolein? Which drug causes this?

A

You use MESNA

Cyclophosphamide causes this acrolein

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24
Q

Is Busulfan CCS or CCNS?

A

CCNS

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25
Q

Is Procarbazine CCS or CCNS?

A

CCNS

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26
Q

Is Dacarbazine and Temozolomide CCS or CCNS?

A

CCNS

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27
Q

Is Carmustine, Lomustine, Semustine, and Streprozocin CCS or CCNS?

A

CCNS

28
Q

How is Estramustine phosphate taken? why is this important?

A

Orally. phosphate is cleaved and binds to beta tubulin

Has antimitotic effects

29
Q

Is Estramustine phosphate CCS or CCNS?

A

CCNS

30
Q

What toxicity does Busulfan have?

A

Pulmonary fibrosis

Hyperpigmentation of the skin

31
Q

What toxicity does Carmustine, Lomustine, Semustine, and Streprozocin have?

A

pulmonary fibrosis and nephrotoxicity

pancreatic steptozotocin

32
Q

What is special about Carmustine, Lomustine, Semustine, and Streprozocin?

A

breakdown in vivo to liberate alkylating and carbamylating species

highly lipophilic

33
Q

What does procarbazine do ?

A

Decreases DNA and RNA protein synthesis

Chromatid breakage and translocation (G1-S phase)

AVOID MAO inhibitors and alcohol

34
Q

What does Dacarbazine and Temozolomide do?

A

methylates DNA and RNA

35
Q

Is Mechlorethamine CCS or CCNS?

A

CCNS

36
Q

Is Cyclophosphamide CCS or CCNS?

A

CCNS

37
Q

Is Chlorambucil CCS or CCNS?

A

CCNS

38
Q

Is Bendamustine CCS or CCNS?

A

CCNS

39
Q

What are drugs containing platinum? CCNS or CCS

A

CCNS

40
Q

What is cisplatin/carboplatin/oxaliplatin MOA?

A

bind to guanine in DNA to form intrastrand crosslinks

41
Q

What is cisplatin/carboplatin/oxaliplatin side effects

A

Nephrotoxicity (biggest)

peripheral neuropathy

ototoxicity

42
Q

What must be checked with cisplatin before use?

A

Renal creatine clearance

If <60ml/min do NOT use

43
Q

What is doxorubacin and Daunorubicin MOA

A

Tight binds between DNA base pairs which blocks topoisomerase II

Remove histones from chromatin

DNA strand breaks

44
Q

What is doxorubacin and Daunorubicin? CCS or CCNS

A

CCNS

45
Q

What is doxorubacins side effect?

A

cardiotoxicity

46
Q

What can prevent doxorubacins side effect?

A

dexrazoxane

47
Q

What is Mitoxantrones MOA

A

Tight binds between DNA base pairs which blocks topoisomerase II which causes strand breaks

48
Q

How does Mitoxantrone differ from doxorubicin?

A

Mitoxantrone does not produce free radicals

49
Q

What MOA do etoposide and tenopside use?

A

form ternary complex with DNA topoisomerase 2

50
Q

Are etoposide and tenopside CCS or CCNS?

A

CCS

51
Q

Are camptothecin, topotecan and irinotecan CCS or CCNS?

A

CCS

52
Q

What is the MOA of amptothecin, topotecan and irinotecan?

A

Inhibit topoisomerase I

53
Q

Side effect of amptothecin, topotecan and irinotecan?

A

diarrhea

54
Q

What is the side effect of bleomycins

A

pulmonary fibrosis and pneumonitis with fever

55
Q

Is Mitoxantrone CCS or CCNS?

A

CCNS

56
Q

What is dactinomycins MOA

A

interacts with dG-dC base pairs and prevents DNA transcription

57
Q

Is dactinomycin CCS or CCNS?

A

CCNS

58
Q

What is the most potent anti-tumor agent known

A

dactinomycin

59
Q

What are the toxicities of dactinomycin

A

oral and GI ulceration and stomatitis

60
Q

Is methotexate CCS or CCNS?

A

CCS

61
Q

Is trimetrexate CCS or CCNS?

A

CCS

62
Q

Is pemetrexed CCS or CCNS?

A

CCS

63
Q

What is the MOA of methotrexate

A

inhibits dihydrofolate reductase to block thymidylic acid synthesis

64
Q

What is the MOA of pemetrexed

A

inhibit thymidylate synthase, GAR formyltransferase, and AICAR formyltransferase

65
Q

What minimizes the toxic effects of folate depletion

A

Leucovorin

66
Q

What medicine do you give Leucovorin with to curb effects

A

Methotrexate

67
Q

What are the toxicities of methotrexate and pemetrexed

A

Oral and GI ulceration
hepatotoxicity
pulmonary toxicity

POD EXAM 3 (2 decks)

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