Cancer Dasgupta Flashcards by Taylor Spry

MOPP

Hodgkins disease

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ABVD

Hodgkins disease

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CHOP

Non-hodgkins

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CMF

Breast

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CAF

Breast

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PACE

Small cell lung cancer

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VIP

Germ Cell

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BIP

Cervical

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M_BACOD

Lymphomas

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BEP

Ovarian

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CVD

Pheochromocytoma

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PEB

testicular

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What are problems with cancer chemotherapy?

dose-limiting toxicity

resistance to chemo

glycoprotein pumps

2nd cancers

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MOA of alkylating agents?

block DNA replication and transcription by adding a methyl group to guanine residue on 2 different spots

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Are alkylating agents CCS or CCNS?

CCNS

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What is special about Mechlorethamine?

It is not excreted

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What is Mechlorethamine used for ?

Hodgkins disease (stage III and IV) in MOPP

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What is special about Cyclophosphamide?

Must be activated by cytochrome P450 in liver

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What is the side effect of Cyclophosphamide?

Hemorrhagic cystitis

SIADH (water intoxication) (democyclin manages)

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What is Cyclophosphamide used for?

Burkitts lymphoma
Acute lymphotic leukemia
Other lymphoma and leukemia

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What is the side effect of chlorambucil?

Hepatotoxicity

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What is chlorambucil used for?

Chronic lymphocytic leukemia (CLL)

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What do you use the lower hemmoragic cystis produced by acrolein? Which drug causes this?

You use MESNA

Cyclophosphamide causes this acrolein

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Is Busulfan CCS or CCNS?

CCNS

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Is Procarbazine CCS or CCNS?

CCNS

Is Dacarbazine and Temozolomide CCS or CCNS?

CCNS

Is Carmustine, Lomustine, Semustine, and Streprozocin CCS or CCNS?

CCNS

How is Estramustine phosphate taken? why is this important?

Orally. phosphate is cleaved and binds to beta tubulin Has antimitotic effects

Is Estramustine phosphate CCS or CCNS?

CCNS

What toxicity does Busulfan have?

Pulmonary fibrosis Hyperpigmentation of the skin

What toxicity does Carmustine, Lomustine, Semustine, and Streprozocin have?

pulmonary fibrosis and nephrotoxicity pancreatic steptozotocin

What is special about Carmustine, Lomustine, Semustine, and Streprozocin?

breakdown in vivo to liberate alkylating and carbamylating species highly lipophilic

What does procarbazine do ?

Decreases DNA and RNA protein synthesis Chromatid breakage and translocation (G1-S phase) AVOID MAO inhibitors and alcohol

What does Dacarbazine and Temozolomide do?

methylates DNA and RNA

Is Mechlorethamine CCS or CCNS?

CCNS

Is Cyclophosphamide CCS or CCNS?

CCNS

Is Chlorambucil CCS or CCNS?

CCNS

Is Bendamustine CCS or CCNS?

CCNS

What are drugs containing platinum? CCNS or CCS

CCNS

What is cisplatin/carboplatin/oxaliplatin MOA?

bind to guanine in DNA to form intrastrand crosslinks

What is cisplatin/carboplatin/oxaliplatin side effects

Nephrotoxicity (biggest) peripheral neuropathy ototoxicity

What must be checked with cisplatin before use?

Renal creatine clearance If <60ml/min do NOT use

What is doxorubacin and Daunorubicin MOA

Tight binds between DNA base pairs which blocks topoisomerase II Remove histones from chromatin DNA strand breaks

What is doxorubacin and Daunorubicin? CCS or CCNS

CCNS

What is doxorubacins side effect?

cardiotoxicity

What can prevent doxorubacins side effect?

dexrazoxane

What is Mitoxantrones MOA

Tight binds between DNA base pairs which blocks topoisomerase II which causes strand breaks

How does Mitoxantrone differ from doxorubicin?

Mitoxantrone does not produce free radicals

What MOA do etoposide and tenopside use?

form ternary complex with DNA topoisomerase 2

Are etoposide and tenopside CCS or CCNS?

CCS

Are camptothecin, topotecan and irinotecan CCS or CCNS?

CCS

What is the MOA of amptothecin, topotecan and irinotecan?

Inhibit topoisomerase I

Side effect of amptothecin, topotecan and irinotecan?

diarrhea

What is the side effect of bleomycins

pulmonary fibrosis and pneumonitis with fever

Is Mitoxantrone CCS or CCNS?

CCNS

What is dactinomycins MOA

interacts with dG-dC base pairs and prevents DNA transcription

Is dactinomycin CCS or CCNS?

CCNS

What is the most potent anti-tumor agent known

dactinomycin

What are the toxicities of dactinomycin

oral and GI ulceration and stomatitis

Is methotexate CCS or CCNS?

CCS

Is trimetrexate CCS or CCNS?

CCS

Is pemetrexed CCS or CCNS?

CCS

What is the MOA of methotrexate

inhibits dihydrofolate reductase to block thymidylic acid synthesis

What is the MOA of pemetrexed

inhibit thymidylate synthase, GAR formyltransferase, and AICAR formyltransferase

What minimizes the toxic effects of folate depletion

Leucovorin

What medicine do you give Leucovorin with to curb effects

Methotrexate

What are the toxicities of methotrexate and pemetrexed

Oral and GI ulceration hepatotoxicity pulmonary toxicity