Cancer dasgupta 2 Flashcards
1
Q
Is Flurouracil CCNS or CCS?
A
CCNS
2
Q
Is Cytarabine CCNS or CCS?
A
CCS
3
Q
Is Gemcitabine CCNS or CCS?
A
CCNS
4
Q
What is Flurouracils MOA?
A
inhibit thymidylate synthase
destabalize DNA by incorporating into it
Alter RNA by incorporating into it
5
Q
What is Cytarabine MOA?
A
inhibit DNA polymerase alpha
6
Q
What is Gemcitabine MOA?
A
inhibit DNA synthesis after formation of active form
dFdCTP
7
Q
Unique toxicity of fluorouracil?
A
Oral and GI ulceration
8
Q
Unique toxicity of cytarabine?
A
Oral ulceration
