Cancer Chemotherapy

Question 1

States that anticancer drugs kill a fixed proportion of a tumor cell population, not a fixed number of tumor cells

Answer 1

Log-kill hypothesis

Question 2

Bleomycin act on what phase of cell cycle

Answer 2

G2

Question 3

Synthesis of cellular components of mitosis is seen in what phase of cell cycle

Answer 3

G2

Question 4

Synthesis of cellular components needed for DNA synthesis is seen in what phase of cell cycle

Answer 4

G1

Question 5

Vinblastine, vincristine, paclitaxel acts on what phase of cell cycle?

Answer 5

M phase

Question 6

Drugs given to alleviate toxic effects of anticancer drugs

Answer 6

Rescue therapy

Question 7

Rescue therapy for methotrexate

Answer 7

Leucovorin (folinic acid)

Question 8

Rescue therapy for cyclophosphamide

Answer 8

Mesna

Question 9

Rescue therapy for doxorubicin

Answer 9

Desrazoxane

Question 10

Rescue therapy for cisplatin

Answer 10

Amifostin

Question 11

Hemorrhagic cystitis is an ADR of

Answer 11

Cyclophosphamide

Question 12

Alkylating agents acts on what phase of cell cycle?

Answer 12

G0

Question 13

Platinum based alkylating agent used in colon cancer

Answer 13

Oxaliplatin

Question 14

3 common ADRs of Cisplatin, Carboplatin and Oxaliplatin

Answer 14

Nephrotoxicity
Peripheral neuritis
Acoustic nerve damage

Question 15

To decrease the nephrotoxicity of cisplatin, it should be administered with

Answer 15

Mannitol with forced hydration

Question 16

2 alkylating drugs that forms hydrogen peroxide which generates free radicals that cause DNA strand scission

Answer 16

Procarbazine

Dacarbazine

Question 17

Busulfan is used in treatment of

Answer 17

CML

Question 18

Pulmonary fibrosis, adrenal insufficiency and skin pigmentation are ADRs of

Answer 18

Busulfan

Spares the bone marrow

Question 19

Alkylating agents that are highly lipophilic allowing ease passage through BBB to the CNS causing toxicity

Answer 19

Nitrosourea (carmustine and lomustine)

Question 20

Carmustine and lomustine are

Answer 20

Nitrosoureas

Question 21

Methotrexate acts on what phase of cell cycle

Answer 21

S

Question 22

Methotrexate inhibits what enzyme

Answer 22

Dihydrofolate reductase

Question 23

5-FU inhibits what enzyme

Answer 23

Thymidylate synthase

Question 24

Cytarabine is a pyrimidine antimetabolite that inhibits what enzyme

Answer 24

Ribonucleutide reductase

With reduced formation of dNTPs

Same MOA with gemcitabine

Question 25

Anticancer that is most specific for the S phase of the cell cycle

Answer 25

Cytarabine

Question 26

Precents microtubule assembly hence causing arrest at metaphase

Answer 26

Vinca alkaloids

Question 27

Areflexia, peripheral neuritis and paralytic ileus are ADRs of

Answer 27

Vincristine

Question 28

Vinca alkaloid that causes myelosuppression

Answer 28

Vinblastine

Question 29

Etoposide and teniposide (podophyllotoxin) inhibits what enzyme

Answer 29

DNA topoisomerase II (gyrase)

Question 30

2 camptothecin drugs

Answer 30

Irinotecan and topotecan

Question 31

Irinotecan is used in what cancer

Answer 31

Metastatic colorectal cancer Topotecan: advanced ovarian CA, and Small cell lung CA

Question 32

Interferes mitotic spindle and prevents microtubule disassembly into tubulin monomers

Answer 32

Taxanes (paclitaxel and docetaxel)

Question 33

Taxanes are used in what cancers

Answer 33

Advance breast and ovarian CA

Question 34

Inhibits topoisomerase I

Answer 34

Camptothecin

Question 35

6 drugs that causes pulmonary fibrosis

Answer 35

BBBAN Me ``` Busulfan Bleomycin Bromocriptine Amiodarone Nitrofurantoin Methotrexate ```

Question 36

Imatinib, dasatinib, nilotinib are

Answer 36

Tyrosine kinase inhibitors

Question 37

Imatinib and other Tyrosine kinase inhibitors are used in what 2 malignancy

Answer 37

CML | GIST

Question 38

Inhibits binding of VEGF to VEGFR leading to inhibition of VEGF signaling

Answer 38

Bevacizumab Inhibits neovascularization

Question 39

Rituximab is used in what malignancy

Answer 39

NHL (low grade)

Question 40

Endogenous glycoproteins with antineoplastic, immunosuppressive and antivaral actions

Answer 40

Interferon-alpha

Question 41

Asparaginase is used in the treatment of what malignancy

Answer 41

ALL

Question 42

Allows DNA transcription and differentiatuon of immature leukemic promyelocytes into mature granulocytes

Answer 42

All-trans retinoic acid Used in acute promyelocytic leukemia

Question 43

Only vitamin that can cure cancer

Answer 43

Vitamin A (all-trans retinoic acid)

Question 44

Flutamide, bicalutamire and nilutamide are

Answer 44

Androgen antagonists Used for treatment of prostate cancer

Question 45

Androgen antagonist used for treatment of surgical castration

Answer 45

Nilutamide

Question 46

Drug that must be administered with the androgen antagonists (flutamide) to prevent acute flare-up umof prostate cancer

Answer 46

GnRH analogs (leuprolide)

Question 47

Leuprolide, gonadorelin and nafareli are

Answer 47

GnRH analogs