Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm Exam 4 > Cancer Chemotherapy > Flashcards

Cancer Chemotherapy Flashcards

1
Q

What do alkylating groups cause

A

DNA cross linking and inhibit cell replication and RNA synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Cyclophosphamide

A

Prodrug given orally or IV

“nitrogen mustard”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Lomustine

A

Prodrug given IV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Cisplatin

A

Causes renal damage and ototoxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Doxirubicin

A

Antibiotic given IV
Blocks DNA and RNA synthesis
Produces FR - heart muscle degeneration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Dantinomycin

A

Intercalates with DNA and interferes with mRNA synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Bleomycin

A

Intercalates with DNA and causes its strand breakage - pulmonary fibrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Methotrexate

A

Inhibits dihydrofolate reductase - myelosuppression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

5-flrorouracil

A

Prodrug that inhibits thymidylate synthetase - inhibits thymidine synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Cytarabine

A

Inhibits DNA polymerase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

6-mercaptopurine

A

Inhibits a number of enzymes needed for purine synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Vincristine/ vinblastine

A

Given IV - binds to microtubules and blocks mitosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Paclitaxel

A

Forms abnormal microtubules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Etoposide

A

Inhibits topoisomerase 2 - unrepairable DNA breaks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Topotecan

A

Inhibits topoisomerase 1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Flutamide

A

Blocks androgen receptor inside cell

17
Q

Abiraterone

A

Inhibits CYP 17 - inhibits androgen synthesis

18
Q

Leuprolid

A

Activates GnRH - synthesizes testosterone - downregulation - strongly decreased testosterone synthesis

19
Q

Tamoxifen

A

Blocks estrogen receptor

SE: cataracts

20
Q

Anastrozole

A

Inhibits aromatase - testosterone isn’t converted to estrogen

21
Q

Prednisone

A

Inhibits immune system functions

Treats leukemias and lymphomas

22
Q

Imitinib

A

Given orally - inhibits protein kinase
SE: edema
Treats CML

23
Q

Bortezomib

A

Allows accumulation of excess proteins - cell death

Treats multiple myeloma

24
Q

Trastazumab

A

Vs. HER2

25
Q

Bevacizumab

A

Blocks VEGF

26
Q

Rituximab

A

Vs. CD20

Treats CLL and RA

27
Q

Ibritumomab

A

Antitumor from mice - severe hypersensitivity

Pharm Exam 4 (4 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions