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Pharm Exam 4 > Aspririn and NSAIDs > Flashcards

Aspririn and NSAIDs Flashcards

1
Q

4 effects of NSAIDs

A

Analgesic
Antipyretic
Anti-inflammatory
Anitplatelet

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2
Q

Use for low dose of NSAIDs

A

For aches and pains

Inhibition of clotting

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3
Q

Use for high dose of NSAIDs

A

Arthritis and pain

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4
Q

Where is acetyl salicyclic acids absorbed more and why

A

In the stomach because it’s an acidic environment

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5
Q

Mechanism of aspirin

A

Inhibits PG metabolism by inhibiting COX

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6
Q

Antipyretic effects of aspirin

A

CNS: counteracts effects of bacterial pyrogens

Mild peripheral vasodilation

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7
Q

What can aspirin cause if given to children

A

Reye’s Syndrome - swelling of tissues around brain

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8
Q

Analgesic effects of aspirin

A

Limited efficacy
Central and peripheral effects due to decreased PG production
May regulate pain

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9
Q

Anti-inflammatory effects of aspirin

A

Decreases signs of inflammation

Decreases immune cell migration and activity

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10
Q

Anticlotting effects of aspirin

A

Irreversible inhibition of platelet COX - prevents synthesis of TAX2

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11
Q

What is death due to with toxic doses of aspirin

A

Pulmonary edema

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12
Q

What effect does aspirin have on the GI tract

A

Salicyclic acid is a direct irritant

Decreased PG production by intestinal mucosa - decreased mucous production and decreased bicarbonate

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13
Q

CNS effects of aspirin

A

Tinnitis and increased respiration rate

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14
Q

Contraindication for aspirin

A

Patients with clotting deficiencies

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15
Q

What happens in patients with nasal polyps taking aspirin

A

Brochospasms

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16
Q

How does aspirin effect pregnancy

A

Inhibits labor

17
Q

2 other toxic effects of aspirin

A

Reduces miosis

Decreased kidney perfusion

18
Q

Why isn’t acetaminophen an NSAID

A

It has no anti-inflammatory or antiplatelet effect

Non narcotic analgesic

19
Q

Overdose of acetaminophen

A

Liver toxicity

20
Q

Toxic effect of acetaminophen

A

Decreased GSH in liver - treat with reducing agent, n-acetylcysteine

21
Q

7 proprionic acid derivatives

A 
Ibuprofen
Naproxyn
Fenoprofen
Ketoprofen
Flurbiprofen
Oxaprozin
Suprofen
22
Q

3 acetic acid derivatives

A

Indomethacin
Tolmetin
Sulindac

23
Q

Indomethacin mechanism

A

Very potent COX inhibitor

24
Q

What can indomethacin treat

A

Patent ductus arteriosis

25
Q

Side effects of indomethacin

A

Thrombocytopenia, aplastic anemia, corneal opacities

26
Q

6 other NSAIDs

A 
Pytoxicam
Diclofenac
Bromfenac
Nepafenac
Etodolac
Nabumetone
27
Q

Celecoxib mechanism

A

Selective COX inhibitor

28
Q

Celecoxib side effects

A

Myocardial infarction and stroke due to increased effect on production of prostacycline

Pharm Exam 4 (4 decks)

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