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Pharm Block 3 > Cancer chemotherapy > Flashcards

Cancer chemotherapy Flashcards

1
Q

How is resistance conferred in cancer therapeutics

A
  1. increased DNA repair
  2. Formation of trapping agents (glutathione)
  3. changes in target enzymes
  4. decreased activation of prodrugs
  5. Inactivation of anticancer drugs
  6. Decreased drug accumulation
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2
Q

What are the rules of Combination Therapy?

A

Each drug should be active when used alone against particular cancer, the drugs should have different mechanisms of action, cross-resistance should be minimal, drugs should have different toxicities

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3
Q

What is Leucovorin used for?

A

increase folate which is inhibited by methotrexate

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Pharm Block 3 (4 decks)

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