Anti-influenza + Anti-Hep + Misc. + Anti-protozoa Flashcards
What are the four drugs used to treat Influenza?
Amantadine, Rimantadine, Oseltamivir, Zanamivir
Which drugs are prophylaxis against Influenza A?
Amantadine, Rimantadine. Give within 48 hours of exposure. Cannot treat H3N2 or H1N1.
What is the mechanism of action of Amantadine and Rimantadine?
Prevent uncoating of virus by binding to protein M2, an ion channel required at the onset of infection to permit acidification of the viral core, which activates viral RNA transcriptase.
What are side effects of Amantadine and Rimantadine?
GI irritation, ataxia, dizziness, slurred speech.
What is the action of Oseltamivir and Zanamivir
Inhibits neuraminidase and viral spread. Neuraminidase is produced by influenza A and B and activate against H3N2 and H1N1 strands.
How are Oseltamivir and Zanamivir administered?
Oseltamivir is orally activated and Zanamivir is given in a nasal spray
What are the adverse effects associated with Osltamivir and Zanamivir?
Oseltamivir has GI disturbances and Zanamivir is associated with cough, through discomfort and bronchospasm (Be very careful with asthmatics)
Which drugs are used to treat viral hepatitis?
Interferon Alpha, Adefovir Dipivoxil, Entecavir, Ribavirin.
What is the action of Interferon Alpha?
Stimulates formation of antiviral proteins and activates host cell RNAse (ribonuclease) that degrades viral mRNA
What are the clinical uses for Interferon Alpha?
Suppressive for Hep B, curative for Hep C
What are the adverse effects of Interferon Alpha?
GI irritation, flu-like symptoms, confusion, depression, neutropenia, reversible hearing loss
What is the mechanism of Adefovir Dipivoxil?
Prodrug Inhibits Hep B DNA polymerase causing chain termination
What are the side effects of Adefovir Dipivoxil?
dose limited nephotoxicity, severe hepatomegaly with steatosis
What is the action of Entecavir?
inhibits DNA polymerase in Hep B
What are the adverse effects of Entecavir?
headache, dizziness, fatigue, and nausea
What is the mechanism of Ribavirin?
inhibits replication in numerous DNA and RNA viruses
What are the clinical uses of Ribavirin?
with Interferon alpha for chronic Hep C Virus treatment and in infants and children with severe RSV infection.