Cancer Chemo

Question 0

Mitotic Inhibitors

Answer 0

Vincristine, and Paclitaxel

Question 1

Alkylating Agents

Answer 1

Cyclophosphamide and Cisplatin

Question 2

Anti-Tumor Antibiotics

Answer 2

Doxorubicin

Question 3

Antimetabolites

Answer 3

Methotrexate

Question 4

Topoisomerase Inhibitors

Answer 4

Irinotecan

Question 5

Targeted Agents for Chemotherapy

Answer 5

Rituximab and Imatinib

Question 6

Bleomycin and Paclitaxel work at what part of the cell cycle?

Answer 6

G2-Mitosis stage

Question 7

MOA of alkylating agents (cyclophosphamide, cisplatin)

Answer 7

a) Highly reactive drug/drug metabolite covalently binds (alkylates) DNA
b) Cell cycle non-specific but are most effective against rapidly dividing cells.
c) DNA damage causes cells to undergo apoptosis

Question 8

Antimetabolites MOA (Methotrexate)

Answer 8

Analogs of endogenous precursors of DNA and RNA; prevent nucleic acid synthesis and thus inhibit cell replication

• Cell cycle specific- most are effective during S phase
• Methotrexate is folic acid analog and blocks dihydrofolate reductase

Question 9

Cell kill is by ________ order kinetics in chemotherapy

Answer 9

First order (Constant fraction)

Question 10

Antitumor Antibiotics MOA and Adverse Rxn (Doxorubicen)

Answer 10

A) Intercalation of DNA (insertion between paired DNA base pairs)
B) Cell cycle non-specific
Adverse rxn: Cardiotoxicity

Question 11

Alkylating agents depend on a functioning _____ tumor suppressor gene (Cyclophosphamide (Nitrogen mustard), Cisplatin(Platinum))

Answer 11

p53

Question 12

Mitotic Inhibitors MOA (Vincristine (polymerization), paclitaxel (depolymerization))

Answer 12

Cause cell cycle arrest in metaphase (M phase specific) by interfering with mitotic spindles.