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USMLE 1 > Cancer Biochemistry > Flashcards

Cancer Biochemistry Flashcards

One-Core Genes - one is sufficient

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USMLE® Step 1 flashcards
1
Q

ABL

A

M/translocation
F/TK
T/CML

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2
Q

BCL -2

A

Translocation > Anti-apoptosis > B Cell lymphoma

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3
Q

CDK 4

A

Amplification/PM >Cell cycle regulation > sarcomas & familial melanomas

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4
Q

Cyclin D1

A

Amplification >Cell cycle regulation > Breast/carcinomas

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5
Q

C -MYC

A

Amplification/Translocation > TF> Lymphomas and Carcinomas

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6
Q

N-MYC

A

Amplification > TF > Neuroblastoma

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7
Q

ERB B2/Her2Neu

A

Amplification > EGFR > Breast

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8
Q

H-RAS/GTPase

A

PM > G-protein/Signal transduction >Bladder & thyroid cancer

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9
Q

K-RAS/GTPase

A

PM > G-protein > Pancreas/colon/lung adenocarcinomas and melanomas

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10
Q

N-RAS/GTPase

A

PM > G-protein > Acute leukemia/melanoma/thyroid cancer

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11
Q

FOS

A

Amplification > AP-1 TF > osteosarcoma

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12
Q

HST

A

Amplification > GF (FGF like) > Stomach

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13
Q

INT 2

A

Amplification > GF > Breast/esophagus/glioblastoma

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14
Q

KIT

A

Constitutive activation > RTK >

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15
Q

MET

A

PM > RTK > Hereditary Papillary Renal tumor

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16
Q

BTK

A

x > Cytoplasmic TK > SCID

17
Q

SRC

A

PM > Cytoplasmic TK > Colon/stomach/Sq.Cell Carcinoma

18
Q

RET

A

Translocation > RTK > MEN 1:{3P}:pancreatic/pituitaryparathyroid & MEN 2:{ATP}: adrenal/thryroid/parathyroid
MEN: multi-endocrine neoplasia syndrome

19
Q

RAF 1

A

Translocation > Serine Threonine Kinase > stomach

20
Q

PIM 1

A

Constitutive activation > STK >T cell lymphoma

21
Q

B-RAF

A

Melanoma

22
Q

B - catenin

A

colon

23
Q

Cyclin E

A

liver

USMLE 1 (5 decks)

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