Cancer

Question 1

Perio connections to disease…
heart?
Liver?
Gut?

Answer 1

Heart - systemic bacteria, atherosclerosis
Liver - SYstemic inflammation, acute phase response
Gut - Swallowing/dysbiosis, endotoxemia

Question 2

What inflammatory cytokines are higher in periodontitis?

Answer 2

C-reactive
IL-6
serum amyloid A

Question 3

Fusobacterium found in what cancer? How associated?

Answer 3

colorectal, higher levels in more dysplastic adenomas, promotes tumorigenesis in mice

Question 4

P. gingivalis connection to cancer?

Answer 4

yes, more progression, GroEL protein

Question 5

3 ways pathogens induce cancer development?

Answer 5

1. dna damage
2. altered beta-catenin
3. pro-inflammatory programs

Question 6

Mechanism of Fusobacterium contributing to cancer

Answer 6

Fap2 protein protects tumor cells from immune attack

Question 7

Tooth loss/perio connection to cancer?

Answer 7

increased risk of head and neck SCC

Question 8

Periodontitis synergizes with what?

Answer 8

HPV, more HPV+ tumors

Question 9

Do the biologic mechanisms for causal link between perio and cancer exist?

Answer 9

yes

Question 10

Which group has H. pylori in the stomach?

Answer 10

sigma

Question 11

What protein in H pylori leads to altered beta catenin signaling?

Answer 11

Cag A

Question 12

Beta catenin how leads to greater tumorigenesis?

Answer 12

enhances cell growth

Question 13

People with tooth loss = how many fold higher risk of H&N Cancer?

Answer 13

2x

Question 14

Perio diease and h&n cancer risk?

Answer 14

3x

Question 15

History of periodontal disease = what % increased risk of ALL cancers?

Answer 15

14%

Question 16

P gingivalis and pancreatic cancer risk?

Answer 16

2-fold greater risk

Question 17

Need what kind of studies to confirm causal relationship between periodisease and cancer

Answer 17

longitudinal