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Pharmacology Test Two > Cancer > Flashcards

Cancer Flashcards

1
Q

Indications for chemo

A

Cell type, palliative, adjunct to micrometastatic, radiosensitization (increase for therapy)

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2
Q

What is the heirarchy of cell death in chemo

A

hematopoietic cells (bone marrow) > epithelial tissue (GI) > mesenchymal

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3
Q

Vincristine, vinblastine, paclitaxel, docetaxel - type of drugs

A

Phase-specific

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4
Q

Cytosine arabinoside, hydroxyurea, methotrexate- type of drugs

A

Non-phase specific

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5
Q

Concern with cyclophosphamide

A

Bladder toxicity- sterile hemorrhagic cystitis

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6
Q

What drug should be substituted for cyclophosphamide in toxicity

A

Chlorambucil

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7
Q

What toxicity is associated with lomustine (CCNU)

A

Hepatotoxicity due to active metabolites from first pass hepatic

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8
Q

What is the toxicity of Cisplatin

A

Nephrotoxic- pre-must fluid load and diurese after; fatal pulm edema in cats

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9
Q

What should substitute for cisplatin

A

Carboplatin

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10
Q

Cross BBB

A

Lomustine, methotrexate, cytosine arabinoside

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11
Q

What hsould not be used in cats because it causes seizures

A

5-flurouracil

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12
Q

What agent causes anaphlyaxis

A

Doxorubicin

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13
Q

Sub for doxorubicin

A

Actinomycin D or Mitoxantrone

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14
Q

Actinomycin D vs Mitoxantrone

A

Actin- non cardiotoxic

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15
Q

Vinca alkyloids- phase or non?

A

Phase specific- M phase

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16
Q

Toxicity- vincristine

A

Vesicant, peripheral neuropathy

17
Q

Vincristine sub-

A

Vinblastine - still a vesicant

18
Q

Anaphylaxis from

A

Doxorubicin, L-asparginine

19
Q

Only non myelosupressive

A

L-asparginine

20
Q

Non-phase specific classes

A

Alkylating, antibiotics, platinum

21
Q

Exception to class cross resistance in alkylating agents

A

Lomustine

22
Q

Pred - indication

A

Lymphoma

23
Q

Osteosarc tx

A

Cisplatin, methotrexate, doxorubicin,

24
Q

Cyclophosphamide- type

A

Alkylating

25
Q

Lomustine- type

A

alkylating

26
Q

Doxorubicin- type

A

Antibiotic

Pharmacology Test Two (6 decks)

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