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Pharmacology drugs > Cancer > Flashcards

Cancer Flashcards

1
Q

how can breast CA be prevented

A

exercise, healthy diet, tamoxifen

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2
Q

name the SERMs for breast CA

A

Tamoxifen (Nolvadex), Raloxifene (Evista)

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3
Q

MOA of SERMs

A

decrease cancer cell growth

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4
Q

Max use of tamoxifen

A

5 years

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5
Q

why should you be careful with SERMs if you don’t have CA

A

Carcinogenic if you don’t have CA

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6
Q

ADR of SERMs

A

stroke*, flushing, bone pain

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7
Q

unlabeled use for SERMs

A

endometrial carcinoma

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8
Q

which SERM is a prodrug?

A

Tamoxifen changes to endoxifen via 2D6

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9
Q

What are some drugs that can cause drug interactions with SERMs

A

Fluoxetine: strong, Sertraline: moderate

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10
Q

Dose of tamoxifen

A

20mg once daily

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11
Q

Name the aromatase inhibitors used to treat breast CA

A

anastrazole (Arimidex), Letrozole (femara)

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12
Q

MOA of aromatase inhibitors

A

inhibits T –> E

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13
Q

Benefits of aromatase i over SERMs

A

decreased stroke risk

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14
Q

ADR of aromatasei

A

Fx, osteoporosis, MSK pain, flushing

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15
Q

treatment of premenopausal breast CA

A

chemo + tamoxifen if ER+, + trastuzumab if HER/neu+

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16
Q

treatment of postmenopausal breast CA

A

ER+ gets tamoxifen or aromatasei + trastuzumab in HER/neu+

17
Q

name the anti-HER2 agents

A

trastuzumab (Herceptin), Lapatinib (Tykerb)

18
Q

Dose for Tykerb

A

250mg 5 tablets once daily

19
Q

MOA of anti HER2 agents

A

change genetic messages from CA cells

20
Q

what can people taking tykerb not eat d/t 3A4 metabolism

A

grapefruit juice, take on empty stomach

21
Q

ADR tykerb

A

GI, acne

22
Q

which HER2 agent need premedication?

A

trastuzumab

23
Q

What workup should you do on pts taking trastuzumab before prescribing?

A

EKG, LVEF d/t cardiac toxicity

Pharmacology drugs (3 decks)

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