Cancer Flashcards
Two major dysfunctions in cancer development
Defective cell proliferation
Defective cell differentiation
normal cells growing in the wrong place @ wrong time
benign
Abnormal cells that serve no useful function & are harmful
malignant
Benign cells are
slow growing; non infiltrating
cells differ slightly from normal cells
grade I
Cells are more abnormal & moderately differentiated
grade II
Cells are very abnormal & poorly differentiated
grade III
Cells are immature & primitive & undifferentiated; cells of origin is difficult to determine
grade IV
Cancer that is precancerous
0 stage
Tumor limited to tissue of origin; localized tumor growth
I stage
Limited local spread
II stage
Extensive local & regional spread
III stage
Metastasis
IV stage
TNM classification
Tumor size & invasiveness (T)
Spreads to lymph nodes (N)
Metastasis (M)
blood cancers (leukemia)
hematologic cancer