Calsium Channel Blockers

Question 1

Calcium

MOA

Answer 1

Act on >>
Voltage gated calcium channel 
L- long lasting
T- transit
N- neurological

Question 2

CCBs types

Answer 2

1. Cardio-selective
   a. Verapamel b. Diltyazm
2. Vasclo-selective
   Nephidepine- amlidepine- isradepine- nimindepine
3. Non selective
   Flunaresem- ceniqsem

Question 3

Niphedipine

Answer 3

((❤️))
Contractions > week -ionotopic effect
AV conduction > week
HR > reflex tachycardia

((BV))
VD> +++
Coronary VD > +++
BP> ⬇️⬇️

Question 4

Verapamel - Diltyazm

Answer 4

((❤️))
Contractions > strong -ionotopic effect
AV conduction > strong
HR > bradycardia

((BV))
VD> week
Coronary VD > week
BP> week

Question 5

Uses»

1. Cardio-selective

Answer 5

1. IHD ((primezel angina))
   ⬇️ myocardial work so O2 demand,⬆️ diastol time, and coronary VD
   2. Supra ventricular tachycardia
      ⬇️conduction
      Block ca channel in SAN

⭐️C/I&raquo_space; in ventricular tachycardia
And WPW syndrome

3. HOCM

Question 6

Uses»

1. Vaso-selective

Answer 6

1. Pripheral ischemic ds
2. Ischemic renal failure
3. HTN in pregnancy 🤰&raquo_space; good effect on uterus cause relaxation
4. Sub-arachnoid hemorrhage

Question 7

C/I»

1. Cardio-selective

Answer 7

1. Casue CHD
2. Sever bradycardia
3. Cases Heart block
4. Constipation bCuz it ⬇️ git motily
5. Salt and water retention
   Bcuz activities RAAS&raquo_space; ankle edema

Question 8

C/I»

1. Vaso-selective

Answer 8

1. Sever ⬇️BP > reflex tachycardia

2. Salt and water retention