Caliciviridae

Question 1

What is unique about the appearance of family Caliciviridae?

Answer 1

They have 32 cup-shaped depressions that give them a unique appearance

Question 2

Describe the virions of family Caliciviridae

Answer 2

Non-enveloped with icosahedral symmetry

Question 3

Describe the genome of family Caliciviridae

Answer 3

Linear, single-stranded, positive sense RNA–genomic RNA is infectious

Question 4

Where does virus replication occur with family Caliciviridae?

Answer 4

Cytoplasm

Question 5

To which genus does feline calicivirus (FCV) belong?

Answer 5

Vesivirus!

Question 6

T or F: clinical syndromes can range from inapparent infections to mild or acute oral and upper respiratory tract disease in cats

Answer 6

True..I didn’t know how else to ask this question :(

Question 7

Some strains of FCV induce lameness known as ?

Answer 7

Limping syndrome

Question 8

What is ‘new’ about a new form of FCV?

Answer 8

Highly virulent forms of FCV have emerged and are associated with a systemic infection that is frequently fatal!

Question 9

How is the virus shed in cats?

Answer 9

In oral, nasal, and conjunctival secretions by direct contact (inhalation, ingestion, conjunctiva)

Question 10

Knowing how the virus is shed, where does it tend to replicate?

Answer 10

Oral and respiratory tissues

Question 11

What are some clinical findings of FCV-associated oral and upper respiratory tract disease?

Answer 11

Tongue ulcers**, rhinitis, gingivostomatitis, pneumonia

Question 12

What can be seen pathologically in FCV associated lameness?

Answer 12

Acute synovitis, thickening of synovial membrane, increased amount of synovial fluid in joint

Question 13

What is the mortality rate of the newly discovered FCV associated virulent systemic disease?

Answer 13

up to 50%

Question 14

T or F: current vaccines protect against the new FCV-VSD

Answer 14

False! Vaccinated cats have been affected

Question 15

T or F: clinical-pathological features of FCV-VSD are similar to those of classical FCV disease

Answer 15

FALSE. They differ substantially

Question 16

What mechanisms could be at play that mutated typical FCV to FCV-VSD

Answer 16

Virus mutations, host and immune factors, environmental and management factors

Question 17

Describe the pathology of FCV-VSD

Answer 17

Ulceration of tongue, pinnae, haired skin
Mild hyperthermia
Sloughing of entire foot pad
Broncho-interstitial pneumonia and necrosis of liver, spleen, pancreas
Endothelial cell infection resulting in vascular injury

Question 18

What are some clinical signs of FCV-VSD?

Answer 18

Pyrexia, edema, crusted lesions, alopecia on nose, lips, ears, around eyes and on footpads, anorexia, jaundice, alopecia, respiratory distress, epistaxis

Question 19

What is a common vaccine type for FCV?

Answer 19

Divalent vaccine with FHV

Modified-live and inactivated parenteral vaccines

Question 20

What are some clinical signs of a pig infected with vesicular exanthema of swine (VES)?

Answer 20

Fever, formation of vesicles on snout, oral mucosa, soles of feet, coronary band, between toes

Question 21

What other diseases is VES clinically indistinguishable from?

Answer 21

Foot and mouth disease, vesicular stomatitis, swine vesicular disease

Question 22

T or F: VES is still present in the U.S.

Answer 22

No, it was declared VES free in 1959

Question 23

Describe the San Miguel Sea Lion Virus

Answer 23

Formation of vesicles in oral cavity/flippers, produces vesicular exanthema-like disease when inoculated into pigs

Question 24

What does norovirus cause?

Answer 24

Gastroenteritis