Caliciviridae Flashcards
What is unique about the appearance of family Caliciviridae?
They have 32 cup-shaped depressions that give them a unique appearance
Describe the virions of family Caliciviridae
Non-enveloped with icosahedral symmetry
Describe the genome of family Caliciviridae
Linear, single-stranded, positive sense RNA–genomic RNA is infectious
Where does virus replication occur with family Caliciviridae?
Cytoplasm
To which genus does feline calicivirus (FCV) belong?
Vesivirus!
T or F: clinical syndromes can range from inapparent infections to mild or acute oral and upper respiratory tract disease in cats
True..I didn’t know how else to ask this question :(
Some strains of FCV induce lameness known as ?
Limping syndrome
What is ‘new’ about a new form of FCV?
Highly virulent forms of FCV have emerged and are associated with a systemic infection that is frequently fatal!
How is the virus shed in cats?
In oral, nasal, and conjunctival secretions by direct contact (inhalation, ingestion, conjunctiva)
Knowing how the virus is shed, where does it tend to replicate?
Oral and respiratory tissues
What are some clinical findings of FCV-associated oral and upper respiratory tract disease?
Tongue ulcers**, rhinitis, gingivostomatitis, pneumonia
What can be seen pathologically in FCV associated lameness?
Acute synovitis, thickening of synovial membrane, increased amount of synovial fluid in joint
What is the mortality rate of the newly discovered FCV associated virulent systemic disease?
up to 50%
T or F: current vaccines protect against the new FCV-VSD
False! Vaccinated cats have been affected
T or F: clinical-pathological features of FCV-VSD are similar to those of classical FCV disease
FALSE. They differ substantially
What mechanisms could be at play that mutated typical FCV to FCV-VSD
Virus mutations, host and immune factors, environmental and management factors
Describe the pathology of FCV-VSD
Ulceration of tongue, pinnae, haired skin
Mild hyperthermia
Sloughing of entire foot pad
Broncho-interstitial pneumonia and necrosis of liver, spleen, pancreas
Endothelial cell infection resulting in vascular injury
What are some clinical signs of FCV-VSD?
Pyrexia, edema, crusted lesions, alopecia on nose, lips, ears, around eyes and on footpads, anorexia, jaundice, alopecia, respiratory distress, epistaxis
What is a common vaccine type for FCV?
Divalent vaccine with FHV
Modified-live and inactivated parenteral vaccines
What are some clinical signs of a pig infected with vesicular exanthema of swine (VES)?
Fever, formation of vesicles on snout, oral mucosa, soles of feet, coronary band, between toes
What other diseases is VES clinically indistinguishable from?
Foot and mouth disease, vesicular stomatitis, swine vesicular disease
T or F: VES is still present in the U.S.
No, it was declared VES free in 1959
Describe the San Miguel Sea Lion Virus
Formation of vesicles in oral cavity/flippers, produces vesicular exanthema-like disease when inoculated into pigs
What does norovirus cause?
Gastroenteritis
