Caldwell Pharm Flashcards
Which 2 drugs have level 1 evidence for use in community acquired pneumonias in a non-ICU patient?
1) Respiratory Fluoroquinolones (Gemi, Moxi, and Levofloxacin) and 2) Beta-lactam + macrolide
Which drugs have level 1 evidence for use in community acquired pneumonia in an ICU patient?
Beta-lactams and respiratory fluoroquinolones
For an ICU patient with CAP what should be used instead of penicillins if there is an allergy? What about a non-ICU pt?
1) For ICU pt: fluoroquinolones and aztreonam and 2) fluoroquinolons
What are the 4 options for Tx of P. aeruginosa CAP?
1) Beta-lactam and Cipro/levofloxacin 2) Beta-lactam and tobramycin 3) Gentamicin and Azithromycin or 4) Gentamicin and Respiratory fluoroquinolone
What are 2 drugs for Tx of acute sinusitis? Which for M. catarrhalis?
1) Amoxicllin and TMP-SMX, M. catarrhalis is resistant to penicillins, so just TMP-SMX
Which 5 drugs can be used for Tx of chronic sinusitis?
1) Clindamycin 2) Cefazolin/metronidazole 3) Cefuroxime/metronidazole 4) Clarithromycin 5) Fluoroquinolones
Which intramuscular and oral agents can be used against streptococcal sore throat? What if penicillin allergy?
Intramuscular = Penicillin G Benzathine; Oral = Penicillin V; If allergic then erythromycin
Which 3 agents can be used for COPD exacerbations?
1) TMP-SMX 2) Doxy and 3) Azithromycin and Clarithromycin
Which 3 agents are used for highly penicillin-resistant pneumococcal infections?
1) Doxycycline 2) Clindamycin and 3) Levofloxacin
2 antibiotics for Legionella:
Fluroquinolone and Azithromycin (Carty/Chen say Erythromycin)
What are 3 agents that can be used for nosocomial pneumonia and MRSA?
Linezolid, Tigecycline, and Vancomycin
A healthy patient with S. pneumoniae should be Tx’d with?
Macrolide, again Carty says ampicillin
An outpatient w/ comorbidities and has S. pneumo should be Tx’d with:
Respiratory fluoroquinolone OR Beta-lactam + Macrolide
What general class of drug is used in CAP patients over 60?
Cephalosporins (2nd gen Loracarbef and Cefuroxime; 3rd gen Cefpodoxime and Ceftriaxone)