Calcium Dynamics in Large neuronal models

Question 1

Calcium is

Answer 1

an important intracellular signalling molecule with rapid effect on the kinetics of many processes

Question 2

The purkinje cell has a very active _______, capable of generating large _________

Answer 2

dendrite, large Ca2+ spikes

Question 3

In modelling the Purkinje cell, when using an exponentially decaying Ca2+ pool, what is an important advantage

Answer 3

only one parameter ß needed to be defined for the entire model

Question 4

When building a large active membrane model that includes Ca2+ dynamics one is faced with a _______
The calcium activated K+ channels do _________
leading to reduce __________ (functionally equivelent to changing the ________________ )

Answer 4

feedback loop
hyperpolarize the membrane
Ca2+ influx
maximum conductance of the Ca2+ channels

Question 5

The exponentially decaying calcium pool describes the change in [Ca2+] in a single compartment as

Answer 5

d[Ca2+]/dt = - Ica/2Fv - ß([Ca2+] - [Ca2+]min)

Question 6

Ica/2Fv describes ________

Answer 6

The change caused by calcium inflow into a compartment with volume v

Question 7

ß([Ca2+] - [Ca2+]min) describes ________-

Answer 7

lumps together many different mechanisms causing a reduction in [Ca2+] and is often referred to as a diffusion rate constant

Question 8

The constant ß lumps together _______________

Answer 8

many different mechanisms causing a reduction in Ca[2+] and is often referred to as the diffusion rate constant or Ca2+ buffering constant

Question 9

A large ß makes

Answer 9

[Ca2+] follow changes in Ica closely with minimal accumlation of Ca2+