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DEMS Unit 3 > Calcium Disorder > Flashcards

Calcium Disorder Flashcards

1
Q

Two HYPERcalcemic Disorders with increase PTH

A
  1. Primary Hyper-parathyroidism
  2. Familial Hypo-CalciUric Hyper-Calcemia
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2
Q

Common clinical features of Primary Hyper-parathyroidism

A

Bones - Stones - Groans - Moans

  1. Bone pain
  2. Kidney stone
  3. Constipation/Abd pain
  4. Psychiatric
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3
Q

Disease Associated with Band Keratopathy

A

Primary Hyper-parathyroidism

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4
Q

Diagnosis for Primary HYPER-parathyroidism

A
  1. increase serum Ca++
  2. increase serum PTH
  3. decrease serum P
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5
Q

Calcimimetic Drug

A

Cinacalcet

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6
Q

Anti-Resorptive Bone Drug

A
  1. Bisphosphonate
  2. Denosumab
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7
Q

Causes of 2nd HYPER-Parathyroidism

A

Inducing PTH secretion:

  1. Increase Phosphorus
  2. Decrease Ca++
  3. Decrease 1,25 vit D
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8
Q

Hypercalcemia of Malignancy Lab

A
  1. Increase Ca++ & decrease P
  2. Decrease PTH
  3. Increase PTH-RP
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9
Q

Most common tumor type leading to Hypercalcemia of Malignancy

A

Lung Cancer (Squamous Cell)

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10
Q

Mechanism of Familial Hypocalciuric Hypercalcemia

A

Damage of Calcium Sensor Receptor

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11
Q

Lab for Familial Hypocalciuric Hypercalcemia

A
  1. Increase serum Ca++
  2. Increase serum PTH
  3. Decrease urine Ca++
  4. Decrease (urine Ca++/Creatinine clearance) < 0.1
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12
Q

HYPO-Calcemia Disorder with decrease PTH

A
  1. HYPO-Parathyroidism
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13
Q

How to correct Total serum Ca++ in HYPO-Proteinemia?

A

Add 0.8 mg/dl to total Calcium for every 1 g/L Albumin is < 4.0 g/L

ADD (4.0-serum albumin)* 0.8

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14
Q

Nutritional Vit D Deficiency Lab

A
  1. Decrease Serum Calcium
  2. Decrease Serum Phosphate
  3. Decrease Serum 25 (OH) Vitamin D
  4. Increase Serum PTH (2nd HPTH)
  5. Increase Serum Alkaline Phosphatase => suggests Osteomalacia
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15
Q

Vit D Disorders

A
  1. Acquired Vitamin D Deficiency
  2. Acquired 1,25 (OH)2 Vitamin D Deficiency
  3. Congenital 1 Alpha Hydroxylase Deficiency

=> “Vitamin D Dependent Rickets Type 1”

  1. Congenital Vitamin D Receptor Deficiency

=> “Vitamin D Dependent Rickets Type 2”

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16
Q

HYPO-Parathyroidism Lab

A
  1. Decrease serum Ca++
  2. Increase serum P
  3. Decrease serum PTH
17
Q

Pseudo-HYPO-Parathyroidism Mechanism?

A

Inactivating mutation of Gs-alpha subunit

18
Q

Pseudo-HYPO-Parathyroidism Lab

A
  1. Decrease serum Ca++
  2. Increase serum P
  3. Increase serum PTH
  4. Short 4th & 5th Metacarpals

DEMS Unit 3 (6 decks)

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