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DEMS Unit 3 > Adrenal Pharmacology > Flashcards

Adrenal Pharmacology Flashcards

1
Q

3 Treatment for Adrenal Insufficiency (Primary + Secondary)

A

Glucocorticoid Replacement

  1. Hydrocortisone
  2. Prednisone
  3. Dexamethasone
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2
Q

Mineralocorticoid Replacement for Tx of Primary Adrenal Insufficiency

A

Fludrocortisone

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3
Q

Primary vs. Secondary Adrenal Insufficiency

A

Primary: Adrenal Gland not making hormone => low Cortisol, low Aldosterone
Secondary: Normal Adrenal Gland but low ACTH => low Cortisol, normal Aldosterone

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4
Q

Which Glucocorticoid Tx can NOT be given SM? Why?

A

Prednisone!!

Requires 11-beta-HSD1 to activate to Prednisolone

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5
Q

Which Enzyme deficiency cause Virilizing HTN? Why?

A 
11-beta-OH
Increase of (1) Deoxycorticosterone (2) Androstenedione
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6
Q

Which Enzyme deficiency cause Virilizing Hypotension? Why?

A

21-OH
Decrease (1) Aldosterone (2) Cortisol
Increase Androstenedione

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7
Q

Which Enzyme Deficiency cause Non-Virilizing HTN?

A

17-alpha-OH
Decrease Androstenedione
Increase Aldosterone

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8
Q

Ketoconazole MOA

A

Inhibit 17-alpha: decrease Cortisol

Inhibit 17,20: decrease DHEA

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9
Q

Cortisol Synthesis Inhibitor

A
  1. Ketoconazole
  2. Metyrapone
  3. Etomidate
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10
Q

Cortisol Receptor Blockers

A

Mifepristone

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11
Q

Enzyme targets for Sex hormone disorders?

A
  1. 5-alpha-reductase

2. Aromatase

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12
Q

Product of 5-alpha-reductase

A

Testosterone –> Dihydrotestosterone

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13
Q

Product of aromatase

A

Testosterone –> Estradiol

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14
Q

Adrenocorticoid Agents order of increasing

  1. Anti-inflammatory effect
  2. Salt-retaining Potency (MC activity)
A
  1. Cortisol
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15
Q

Adrenocorticoid agent with NO MC activity?

A

Dexamethasone

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16
Q
  1. Aldo Antagonist?

2. Why useful?

A
  1. Spironolactone, Eplerenone

2. K+ sparing

17
Q

Loop diuretic waste K+ and Ca++

18
Q

Thiazie diuretic waste K+ and spare Ca++

19
Q

Sodium channel blockers

A
  1. Amiloride

2. Triamterene

20
Q

APA treatment vs. IPA treatment

A

APA: (1) Aldo Antagonist (2) Surgery
IPA: (1) Aldo Antagonist (2) BP meds (CCB, ACEI, ARB)

21
Q

CCB

A
  1. Nifedipine
  2. Diltiazem
  3. Verapamil
22
Q

Order CCB increasing order:

1. Dilation vessels

23
Q

CCB increase HR

A

Nifedipine

24
Q

CCB decrease HR

25
Q

Phenoxybenzamine

A

irreversible alpha 1/2 antagonist

26
Q

Terazosin - Doxazosin

A

reversible alpha 1 antagonist

27
Q

Metoprolol vs. Labetalol

A

Metoprolol: beta-1 blocker
Labetalol: alpha 1 / beta 1/2 blocker

28
Q

Tx for Pheochromocytoma

A
  1. alpha 1 blocker
  2. beta 1 blocker
  3. SURGERY!!

DEMS Unit 3 (6 decks)

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