Calcium Channel Antagonists

Question 1

NCX (polarized) exchanges what?

Answer 1

3 sodium into cell for 1 Ca out of cell

Question 2

NCX (depolarized) exchanges what?

Answer 2

3 sodium out of cell for 1 Ca into cell

Question 3

Na,K ATPase exchanges what?

Answer 3

2 Ka into cell for 3 Na out of cell

Question 4

which type of calcium channels are also referred to as dihydropyridine receptors? what is their function?

Answer 4

L-type CaV channels, they control contraction both in the heart and in skeletal muscle cells

Question 5

what 3 cardiac functions do CCBs decrease?

Answer 5

heart rate, AV-conduction, and contractility

Question 6

*CCBs decrease HR and O2 demand while promoting vasodilation and increase oxygen supply

Answer 6

.

Question 7

CCBs cause a significant reduction in ____, but not ______

Answer 7

afterload, preload

Question 8

Verapamil binds to the _ binding site

Answer 8

V

Question 9

diltiazem binds to the _ binding site

Answer 9

D

Question 10

nifedipine binds to the _ binding site

Answer 10

N

Question 11

diltiazem and verapamil target _____ cells

Answer 11

cardiac

Question 12

nifedipine targets ______ _____

Answer 12

smooth muscle

Question 13

nifedipine causes a decrease in arterial resistance and causes?

Answer 13

reflex tachycardia because it does not slow cardiac contractility