C341 Thyrotoxicosis

Question 0

Grave’s disease is accounted for how many cases of thyrotoxicosis?

Answer 0

60-80%

Question 1

Define thyrotoxicosis

Answer 1

State of thyroid hormone excess not of thyroid function

Question 2

High Iodine intake is associated with?

Answer 2

The increase incidence of Grave’s disease

Question 3

At what age does Grave’s dse typically occur?

Answer 3

2nd to 5th decade of life, also occurs in the elderly

Question 4

Is STRESS is an important environmental factor?

Answer 4

True

Question 5

Is SMOKING a major risk factor for Grave’s disease?

Answer 5

False, only MINOR.

But is a MAJOR risk factor for the development of OPTHALMOPATHY.

Question 6

What Ab is responsible for the hyperthyroidism found in Grave’s disease?

Answer 6

Thyroid stimulating immunoglobulin (TSIg) w/c is synthesized in the:
• thyroid gland
• bone marrow
• lymph nodes

Question 7

What is the significance of Thyroid peroxidase antibodies?

Answer 7

• should be also tested in patients with GD (occurs up to 80% of cases)
• readily measurable marker of autoimmunity

Question 8

Do sudden increases in iodine intake may precipitate Grave’s disease?

Answer 8

True

With a threefold increase in occurrence of Grave’s disease POSTPARTUM

Question 9

What is a useful monitoring assay for pregnant Grave’s patients?

Answer 9

Presence of TSH-binding inhibiting immunoglobulins (TBII)