C341 Disorders Of The Thyroid Gland

Question 0

AnaReview: Char of N° thyroid gland

Answer 0

• Size: 12-20g
• highly vascular
• Consistency: Soft

Question 1

Autoimmune disorders of the thyroid gland can result to?

Answer 1

• Stimulation of overproduction of thyroid hormones (thyrotoxicosis)
• Glandular destruction and hormone deficiency (hypothyroidism)

Question 2

When does the thyroid gland develop from the floor of the primitive pharynx?

Answer 2

3rd week of gestation

Question 3

When does thyroid hormone synthesis begin?

Answer 3

11th week of gestation

Question 4

What does the ultimobranchial body (neural crest derivative) give rise to?

Answer 4

Thyroid medullary C cells (prod. Calcitonin)

Question 5

What dictates thyroid cell development and induction of thyroid specific genes

Answer 5

• thyroid transcription factor 1 & 2

* paired homeobox-8

Question 6

Most useful physiologic marker of thyroid hormone action

Answer 6

Thyroid stimulating hormone

Question 7

TSH subunit common to other glycoprotein hormones (LH, FSH, hCG)

Answer 7

Alpha-subunit

Question 8

TSH subunit unique to TSH

Answer 8

Beta-subunit

Question 9

Is thyroid axis a classic example of an endocrine feedback loop?

Answer 9

True

Question 10

Thyroid hormones act predominantly through what receptor to inhibit TRH and TSH production

Answer 10

Thyroid hormone receptor B2

Question 11

Set-point of the thyroid axis is established by?

Answer 11

TSH

Question 12

Major positive regulator of TSH synthesis and secretion

Answer 12

Thyrotropin Releasing Hormone