C2 The biology of dyspepsia 2: from cells to molecules

Question 1

What receptors do GPCR ligands recognise in the parietal cell?

Answer 1

M3 muscarinic acetylcholine receptor
H2 histamine receptor
CCK2 receptor

Question 2

Are all GPCRs potential drug targets?

Answer 2

no

Question 3

What are the other receptors apart from GPCRs and what do they do?

Answer 3

receptor tyrosine kinase-RTK: signalling via serine/threonine kinase proteins
nuclear receptors:nucleus, transcription
ion channels

Question 4

What are the 3 different classes of membrane proteins?

Answer 4

1) integral membrane proteins
2) lipid modified membrane proteins
3) accessory membrane proteins

Question 5

What are the two types of ion channels?

Answer 5

voltage gated

ligand gated

Question 6

What is diffusion like of ion channels?

Answer 6

down electrochemical gradient

Question 7

What are the 3 solute transporters?

Answer 7

1) uniporter
2) antiporter
3) symporter

Question 8

What is required in solute transporters?

Answer 8

conformational change

Question 9

What are the 2 different ATP-dependent transport?

Answer 9

1) ATP-dpendent ion pumps

2) ABC transporters