C19 Tumor Immunology

Question 1

Tumor from bone and cartilage and lower incidence

Answer 1

Sarcoma

Question 2

Tumor that develops from endodermal or ectodermal tissues (skin, glands), most malignant tumor’s including breast, colon, lung

Answer 2

Carcinomas

Question 3

B cell receptors fine tuned

Somatic hyper mutation in antigen binding region of BCR

Proliferation to select mutations that have increased binding

Answer 3

Affinity maturation

Question 4

B cell change of constant Fc region

Answer 4

Class switching

Question 5

Ligation by this ligand is required for both class switching and hypermutation, which is found on surface of activated helper T cells

Answer 5

CD40L

Question 6

T cell dependent activated IgG, IgA or IgE antibodies are

Answer 6

affinity matured (AGE)

Question 7

Changed by class switching

Answer 7

Fc region of variable region

Question 8

Two keys required for beginning B cell activation

Answer 8

One – cross-linking B cell receptors BCR

Two – Costimulatory contact

Question 9

CD40L are found on the surface of what molecule

Answer 9

Helper T cells

Question 10

CD40 proteins are found on the surface of what cell

Answer 10

B cells