2013 Immunology Kuby C2 Flashcards
What Organ is B cell development linked to?
No particular organ Sharks liver to kidney to spleen devo shift Herps liver to spleen to marrow Bony fish kidney Birds bursa of Fabricius
What adaptive immune tissue is present in all vertebrates?
GALT
Gut associated lymphoid tissue
What organ requires the development of T cells?
Thymus
In what lymphoid organs do birds complete B cell development?
Bursa of Fabricius
Including the bone marrow and thymus, what organs regulate the development of immune cells from immature precursors?
Primary lymphoid organs
Including the spleen lymph nodes and specialize sites in the gut and other mucosal tissue what organs coordinating counter of antigen with antigen specific lymphocytes and their development into effector and memory cells?
Secondary lymphoid organs
From what single cell type to all functionally specialized mature blood cells arise from?
Hematopoietic stem cell (HSC)
What is the normal state of HSCs?
Quiescent
HSC cells that do not self renew become what?
Progenitor cells
What are the two broad lineage commitments of the HSC?
CMP common myeloid-erythroid progenitor
CLP common lymphoid progenitor
In what subphylum did adaptive immunity depending on lymphocytes and mediated by anti-bodies and T cells evolve?
Vertebrates
