C16/28 - Synthetic Routes Flashcards
Alkene to alcohol
Addition (hydration)
H2O (steam)
H3PO4 catalyst
Alcohol to alkene
Elimination
Conc. H2SO4 catalyst.
Alkene to alkane
Addition
H2
Ni catalyst
Alkane to haloalkane
Radical substitution
Halogen/UV light
Haloalkane to primary alcohol
Nucleophilic substitution
NaOH (aq)
Primary alcohol to haloalkane
Substitution
Sodium halide/H2SO4
Alkene to haloalkane
Addition (halogenation)
Hydrogen halide
Primary alcohol to carboxylic acid
Reflux [O]
Acidified K2Cr2O7/ H2SO4
Primary alcohol to aldehyde
Distillation [O]
K2Cr2O7 / H2SO4
Aldehyde to primary alcohol
Distillation [R]
NaBH4/H2O
Secondary alcohol to ketone
Reflux [O]
K2Cr2O7 / H2SO4
Primary alcohol to ester
Carboxylic acid/H2SO4
Esterification
Haloalkane to nitrile
Nucleophilic substitution
NaCN in ethanol
Haloalkane to amine
Nucleophilic substitution
NH3/ethanol
Nitrile to carboxylic acid
Hydrolysis
H2O/HCl