C1/2

Question 1

Enzyme inducers

Answer 1

^ enzyme activity > v [drug]
PC BRAS
Phenytoin
Carbamazepine
Benzos / barbiturates
Rifampicin
Alcohol (Chronic)
Sulfonylureas

Question 2

Enzyme inhibitors

Answer 2

v enzyme activity > ^ [drug]
AO DEVICES
Allopurinol
Omeprazole
Disulfram
Ezithromycin
Valproate
Isoniazid
Ciprodfloxacin
Ethanol (acute)
Sulfonamines eg. sulfasalazine

Question 3

Stopping drugs before surgery

Answer 3

I LACK OP
Insulin (variable)
Lithium (day before)
Anticoag (variable)
COCP / HRT (4 weeks before)
K sparing diuretics (day of)
Oral hypoglycaemic (variable)
Peridonil ie. ACEi (day of)

Question 4

Prescribing acronym

Answer 4

PReSCRIBER
Pt details
Reaction ie. allergy
Sign
Contraindications
Route
IV fluids
Blood clot prophylaxis
Emetic (anti)
Relief (pain)

Question 5

Common contraindications

Answer 5

1. Bleeding
2. NSAIDs
3. Aspirin
4. Steroids
5. Anti-hypertensives

Question 6

SEs/CIs of steroids

Answer 6

STEROIDS
Stomach ulcers
Thin skin
Edema
R / L HF
Osteoporosis
Infection
Diabetes
Cushing’s Syndrome

Question 7

SEs/CIs of NSAIDs

Answer 7

No urine (RF)
Systolic dysf (HF)
Asthma
Indigestion
Dyscrasia (Clotting abnormalities)

Question 8

SEs/CIs of Antihypertensives

Answer 8

Hypotension
Bradycardia (BXs)
Electrolyte abnormalities (Diuretics / ACEi)

Question 9

SE of ACEi

Answer 9

e.g. ramipril
Electrolyte abnormalities
Dry cough

Question 10

SE of BXs

Answer 10

e.g. bisoprolol / propanolol
Cough in asthmatics
Bradycardia

Question 11

SE of CCBs

Answer 11

e.g. verapamil
Peripheral oedema
Flushing

Question 12

SE of diuretics

Answer 12

Renal failure
Electrolyte disturbances
Thiazides > gout
K sparing e.g. spironolactone > gynaecomastia

Question 13

What antiemetic is CI in people with Parkinson’s

Answer 13

Metoclopramide (dopamine agonist)

Question 14

Which dopamine agonist crosses the BBB?

Answer 14

Metoclopramide
NOT domperidone (safe antiemetic in Parkinson’s)`