C-type lectins

Question 1

Por que friend, what is a C-type lectin?

Answer 1

MBL and lung surfactant proteins A and D which recognise carbs on the surface of pathogens.

Question 2

And what, pray tell, does the C in C-type lectin stand for?

Answer 2

Calcium type lectin

Question 3

What domains does CTL have?

Answer 3

homologous carb-recognition domains that mediate sugar binding

Question 4

What is the subgroup called and why?

Answer 4

COLLECTINS because of COLlagen-like domain and LECTIN domain.

Question 5

What do collectins do?

Answer 5

target carb structures on pathogen surfaces, resulting in the agglutination of microorganisms and clearance.

Question 6

Which molecules are included under the heading ‘collectins’?

Answer 6

MBP and lung surfactant proteins A and D

Question 7

What does the basic unit look like? Draw and label it.

Answer 7

Trimer, consisting of a short N terminal region, a collagen like triple helix, an alpha helical coiled-coil neck region and 3 globular c-terminal CRD (carb recognition domain)

Question 8

How many of the basic unit fuckers make up a MBP? and what are MBP A and C?

Answer 8

3. and MBP A and C are calcium-dependent animal lectins found in the serum and liver.

Question 9

What does MBP have weak/strong affinities for?

Answer 9

Weak intrinsic affinity for monovalent sugar ligands, but strong for multivalent sugar ligands.

Question 10

What does low levels of MBP in the serum mean?

Answer 10

Susceptible to recurrent bacterial and fungal infections!