C-reactive protein shakes

Question 1

For what i believe is the third time, what, darling self, is C-reactive protein?

Answer 1

A prototypic acute-phase reactant with HUGE increases in serum concentration following tissue infection or injury. Recognition includes phospholipids on pathogens and damaged self cells.

Question 2

WHAT ARE the serum pentraxins? hint: there are 4

Answer 2

CRP, serum amyloid p-component (SAP), pentraxins and lectins.

Question 3

What is the function of CRP?

Answer 3

Non-specific immune defence. Serum conc increases 1000 fold in response to infection and injury. CAN ACTIVATE COMPLEMENT.

Question 4

What happens for CRP to activate the complement?

Answer 4

when crp is bound to a suitable ligand, it binds C1q and activates complement via the CLASSICAL route.

Question 5

How does it go on with immune clearance?

Answer 5

it recognises receptors on immune cells, leading to the clearing of bound ligands.

Question 6

Clinical aspects of CRP?

Answer 6

Universally used as a clinical indicator of tissue infection/injury/inflammation. NO CRP DEFICIENCY HAS EVER BEEN FOUND.

Question 7

CRP vs AUTOIMMUNE?

Answer 7

Nope son, recognition and removal of nuclear debris prevents generation of autoantibodies

Question 8

CVD?

Answer 8

CRP implicated, but shit son, causal or effect? wILL WE EVER TRULY KNOW