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FRCA Anaesthesia > C&P: Non-depolarizing Muscle Relaxants > Flashcards

C&P: Non-depolarizing Muscle Relaxants Flashcards

1
Q

Aminosteroid muscle relaxants

A

Vecuronium, Rocuronium, Pancuronium

All increased duration of action in renal failure

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2
Q

Benzylisoquinolinium muscle relaxants

A

Atracurium, cis-atracurium, Mivacurium, Gallamine, Turbocare

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3
Q

Monoquaternary muscle relaxants

A

Vecuronium, rocuronium

both aminosteroids

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4
Q

Bisquaternary muscle relaxants

A

Pancuronium (aminosteroid)

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5
Q

Vecuronium: Structure

A

monoquaternary

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6
Q

Vecuronium: Dose (mg/kg)

A

0.1

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7
Q

Vecuronium: Onset/duration

A

medium onset medium duration

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8
Q

Vecuronium: Protein Bound (%)

A

10

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9
Q

Vecuronium: Metabolism/elimination in bile/elimination in urine

A

Metabolism: 20% (deacetylation)
Elimination in bile: 70%
Elimination in urine: 30%

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10
Q

Vecuronium: Effect in renal failure

A

Prolonged action (all the aminosteroids)

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11
Q

Rocuronium: Structure

A

Monoquaternary

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12
Q

Rocuronium: Dose (mg/kg)

A

0.6 (0.9 RSI)

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13
Q

Rocuronium: Onset/duration

A

rapid onset, medium duraiton

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14
Q

Rocuronium: Protein Bound (%)

A

10

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15
Q

Rocuronium: Metabolism/elimination in bile/elimination in urine

A

Metabolism: <5% (deacetylation)
Elimination in bile: 60%
Elimination in urine: 40%

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16
Q

Rocuronium: Effect in renal failure

A

Prolonged effect

17
Q

Atracurium: Structure

A

Benzylisoquinolinium

10 stereoisomers

18
Q

Atracurium: Dose (mg/kg)

A

0.5

19
Q

Atracurium: Onset/duration

A

medium onset, medium duration

20
Q

Atracurium: Protein Bound (%)

A

15

21
Q

Atracurium: Metabolism/elimination in bile/elimination in urine

A

Metabolism: 90% (hoffman degradation and ester hydrolysis)
Elimination in bile: 0%
Elimination in urine: 10%

22
Q

Atracurium: Effect in renal failure

A

No change

23
Q

Cis-atracurium: Dose (mg/kg)

A

0.2

24
Q

Cis-atracurium: Onset/duration

A

medium onset, medium duration

25
Q

Cis-atracurium: Protein Bound (%)

A

15

26
Q

Cis-atracurium: Metabolism/elimination in bile/elimination in urine

A

Metabolism: 95%
Elimination in bile: 0%
Elimination in urine: 5%

27
Q

Cis-atracurium: Effect in renal failure

A

No change

28
Q

Mivatracurium: Structure

A

Benzylisoquinolinium

3 stereoisomers

29
Q

Mivatracurium: Dose (mg/kg)

A

0.2

30
Q

Mivatracurium: Onset/duration

A

medium onset, short duration

31
Q

Mivatracurium: Protein Bound (%)

A

10

32
Q

Mivatracurium: Metabolism/elimination in bile/elimination in urine

A

Metabolism: 90% (by plasma cholinesterases)
Elimination in bile: 0%
Elimination in urine: 5%

33
Q

Mivatracurium: Effect in renal failure

A

No change

FRCA Anaesthesia (10 decks)

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