Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

FRCA Anaesthesia > C&P: Intravenous Induction Agents > Flashcards

C&P: Intravenous Induction Agents Flashcards

Cross and Plunkett parroting

1
Q

Chemical Composition: Thiopental

A

Thiobarbiturate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Chemical Composition: Methohexital

A

Oxybarbiturate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Chemical Composition: Propofol

A

2,6 Di-isopropylphenol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Chemical Composition: Ketamine

A

Phenylcyclidine derivitave

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Chemical Composition: Etomidate

A

Imidazole ester

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Dose (mg/kg): Thiopental

A

3-7

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Dose (mg/kg): Methohexital

A

1-1.5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Dose (mg/kg): Propofol

A

1-2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Dose (mg/kg): Ketamine

A

1-2 (IV), 5-10 (IM)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Dose (mg/kg): Etomidate

A

0.3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

pKa: Thiopental

A

7.6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

pKa: Methohexital

A

7.9

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

pKa: Propofol

A

11.0

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

pKa: Ketamine

A

7.5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

pKa: Etomidate

A

4.0

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

pH in solution: Thiopental

A

10.5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

pH in solution: Methohexital

A

11

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

pH in solution: Propofol

A

6-8.5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

pH in solution: Ketamine

A

3.5-5.5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

pH in solution: Etomidate

A

8.1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Vol of Distribution (L/kg): Thiopental

A

2.5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Vol of Distribution (L/kg): Methohexital

A

2.0

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Vol of Distribution (L/kg): Propofol

A

4.0

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Vol of Distribution (L/kg): Ketamine

A

3.0

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Vol of Distribution (L/kg): Etomidate

A

3.0

26
Q

Protein Binding (%): Thiopental

A

80

27
Q

Protein Binding (%): Methohexital

A

60

28
Q

Protein Binding (%): Propofol

A

98

29
Q

Protein Binding (%): Ketamine

A

25

30
Q

Protein Binding (%): Etomidate

A

75

31
Q

Racemic?: Thiopental

A

Yes

32
Q

Racemic?: Methohexital

A

Yes

33
Q

Racemic?: Propofol

A

No

34
Q

Racemic?: Ketamine

A

Yes

35
Q

Racemic?: Etomidate

A

Yes

36
Q

Action: Thiopental

A

Increased GABA A opening, leading to increased Cl- current

37
Q

Action: Methohexital

A

Simulates GABA, inhibits NMDA

38
Q

Action: Propofol

A

Inhibits NMDA and opioid mu receptors (stimulates K and D)

39
Q

Action: Ketamine

A

Stimulates GABA

40
Q

Action: Etomidate

A

Nil

41
Q

Metabolites, ?active: Thiopental

A

Oxidation with active metabolites

42
Q

Metabolites, ?active: Methohexital

A

Unknown with minimal activity

43
Q

Metabolites, ?active: Propofol

A

Glucuronidation hydroxylation with inactive metabolites

44
Q

Metabolites, ?active: Ketamine

A

N-Demethylation hydroxylation with active metabolites

45
Q

Metabolites, ?active: Etomidate

A

Plasma and hepatic esterases with inactive metabolites

46
Q

Clearance (ml/(kg*min): Thiopental

A

3.5

47
Q

Clearance (ml/(kg*min): Methohexital

A

11

48
Q

Clearance (ml/(kg*min): Propofol

A

30-60

49
Q

Clearance (ml/(kg*min): Ketamine

A

17

50
Q

Clearance (ml/(kg*min): Etomidate

A

10-20

51
Q

Elimination Rate (hours): Thiopental

A

6-15

52
Q

Elimination Rate (hours): Methohexital

A

3-5

53
Q

Elimination Rate (hours): Propofol

A

5-12

54
Q

Elimination Rate (hours): Ketamine

A

2

55
Q

Elimination Rate (hours): Etomidate

A

1-4

56
Q

Hypersensitivity: Thiopental

A

Anaphylaxis 1:20,000

57
Q

Hypersensitivity: Methohexital

A

More common than 1:20,000 (ie theopental), but less severe

58
Q

Hypersensitivity: Propofol

A

Nil

59
Q

Hypersensitivity: Ketamine

A

Rashes in 15%

60
Q

Hypersensitivity: Etomidate

A

Rare

FRCA Anaesthesia (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions