C. Arachidonic Acid Metabolism and NSAIDs

Question 1

What is the most widely used self-prescribed drug class?

Answer 1

NSAIDs

Question 2

Give 3 examples of NSAIDs

Answer 2

Aspirin
Ibuprofen
Naproxen 
Nimesulide 
Meloxicam
Diclofenac
Indomethacin
Flubiprofen
Fenbufen
Diflunisal

Question 3

What are the main Actions of NSAIDS

Answer 3

1. Anti-inflammatory
2. Analgesic
3. Anti-pyretic

Question 4

What are the common side effects of NSAIDs?

Answer 4

Prolonged use can cause irritation and damage to the GI

Ulcer complications

Renal complications / death

Bleeding

Question 5

What is the molecular target of NSAIDs and how do they act on the molecular target?

Answer 5

NSAIDs inhibit the enzyme cyclo-oxygenase (COX)

Question 6

What is the other name for cyclo-oxygenase?

Answer 6

Prostaglandin H2

Question 7

What is COX responsible for ? What does it do?

Answer 7

Cox is responsible for one step in the conversion of membrane phospolipids in prostanoids. Prostanoids will then bind to their receptors and elicit many cellular responses