Buzzwords

Question 0

EM: primarily large sub epithelial deposit “humps” with normal foot processes

Answer 0

Post-Strep GN

Question 1

LM: tram track appearance of GBM capillary walls

Answer 1

MPGN

Question 2

“Spike and dome” on silver stain

Answer 2

Membranous nephropathy

Question 3

EM: irregular electron dense structure in lamina with ribbon like appearance

Answer 3

dense deposit disease

Question 4

Ribbon like appearance - C3 nephritic factor

Answer 4

Dense deposit disease

Question 5

Diffuse effacement of podocytes

Answer 5

minimal change disease and focal segmental glomerusclerosis (FSGS)

Question 6

EM: basket weave appearance

Answer 6

Alport syndrome

Question 7

Hypercellularity

Answer 7

Post Strep GN
MPGN
Lupus nephritis

Question 8

LM: glomerular crescents

Answer 8

RAPIDLY PROGRESSIVE GN disease:

• anti GBM Ab related diseases
• immune complex mediated crescent in glomerulonephritis
• pauci-immune crescentic GN

Question 9

Linear pattern with IgG

Answer 9

Anti GBM Ab related disease- Goodpastures

Question 10

Large kidneys

Answer 10

Hydronephrosis
Myeloma
ARF
PKD (polycystic kidney disease)

Question 11

Gross morph: grain leather with normal to small kidneys

Answer 11

Arterionephrosclerosis (Benign Nephrosclerosis)

Question 12

Histo path: Hyaline arteriolosclerosis

Answer 12

Arterionephrosclerosis

Diabetic nephropathy

Question 13

Histo path: fibroelastic hyperplasia of larger arteries

Answer 13

Arterionephrosclerosis

Question 14

Gross: flea bitten appearance

Answer 14

Malignant hypertension

Question 15

LM: onion skin appearance of large arteries

Answer 15

Malignant hypertension

Question 16

PE: abdominal bruit (rare)

Answer 16

Renal artery stenosis

Question 17

Angiogram: “beaded” appearance of arteries

Answer 17

Renal artery stenosis

Question 18

Later pathology of a depressed, pale grey scar

Answer 18

Embolic renal disease

Question 19

Gross: “sponge like” appearance

Answer 19

Autosomal recessive PKD

Question 20

Gross: no normal parenchyma visible on kidney due to immense number of cysts

Answer 20

autosomal dominant PKD

Question 21

Autoantibodies detected at or genetic defects at ADAMTS13

Answer 21

Thrombotic thrombocytopenia purpura (TTP)

Question 22

Gross: patchy or diffuse cortical necrosis

Answer 22

Thrombotic microangiopathies

Question 23

Cysts at corticomedullary junction

Answer 23

Nephronophtisis (medullary cystic disease complex)

Question 24

Gross: scarring and deformity at calyces and or pelvises: blunting out of papillae and deformity of calyces

Answer 24

Chronic pyelonephritis (also might consider hydronephrosis for blunting of papillae)

Question 25

Histo path: “thyroidization” of tubules

Answer 25

Chronic pyelonephritis

Question 26

Renal papillary necrosis

Answer 26

Analgesic nephropathy

Question 27

Tubular epithelial cell injury

Answer 27

Acute tubular injury

Question 28

Histo path: abnormal cells with numerous mitochondria

Answer 28

Oncocytoma

Question 29

Can result due to trisomy 7, 16, or 17 or loss of Y chromosome

Answer 29

Papillary renal cell carcinoma

Question 30

Invades renal vein

Answer 30

Clear cell renal cell carcinoma

Question 31

Tumor with granular eosinophilic cytoplasm and increased mitochondria

Answer 31

Oncocytoma

Question 32

Brown “muddy” casts

Answer 32

Acute tubular necrosis

Question 33

c-ANCA

Answer 33

Wegener’s

Question 34

p-ANCA

Answer 34

Microscopic polyangitis or Churg-Strauss if with eosinophilia, asthma, granulmatous

Question 35

Congo red stain with Apple green biferengince

Answer 35

Amyloidosis

Question 36

Transthyretin

Answer 36

Improperly folded mutant protein (amyloidosis)

Question 37

Child eats hamburger later with GI/flu like that gets renal failure, oliguria, hematuria

Answer 37

Typical HUS (diarrhea +)