Busty Flashcards
Exposed-uninfected
HIV resistant, only some are ccr5 neg-homozygous
Rapid progressors
HIV into AIDS within 3 years
Long term non-progressors
HIV for 20+years without AIDS
Elite controllers
HIV so low can barely be detected, <50copies/mL
Vif protein
Viral infectivity protein, required for infection
Vpu protein
Viral protein unknown function – for virus release
Non-permissive cells
Have anti-vpu and APOBEC3g
APOBEC3G
Anti-vif protein
Permissive cells
Lack anti-vpu and lack APOBEC3G, can be infected by viruses that also lack vif and vpu
2 routes of entry for neurotropic viruses
Hematogenous and neural
CNS abscesses
Bacterial only!
Kernig Sign
Resistance when try to flex hip and extend knee, pt flat
Brudzinski Sign
Pt flat, try to flex neck, knees legs flex reflexively
Confusion, hydrophobia
Rabies
Centripetal and centrifugal viral spread
Rabies
Rabies Rx
Depends on inoculating animal, vaccine and Ig
Scrapie
Sheep spongiform encephalopathies
Insomnia
CJD
Startle Myoclonus
CJD
M/M129
Higher risk for vCJD, instead of valine
Cortical blindness
CJD
Young people spongiform
vCJD, old is regular CJD