Bulk Transport Flashcards
Process by which cells take in substances from outside of the cell by engulfing them in a vesicle.
ENDOCYTOSIS
Endocytosis is important for plasma membrane homeostasis, modulation of signal transduction, drug delivery, pathogen entry, and nutrient uptake
IMPORTANCE OF ENDOCYTOSIS
is important for plasma membrane homeostasis, modulation of signal transduction, drug delivery, pathogen entry, and nutrient uptake
Endocytosis
Types of endocytosis:
Pinocytosis
Phagocytosis
(literally, “cell drinking”)
Pinocytosis
is a form of endocytosis in which a cell takes in small amounts of extracellular fluid.
Pinocytosis
Cell eating
Phagocytosis
Takes in larger substances (bacteria)
Phagocytosis
also called clathrin-mediated endocytosis
Receptor-mediated endocytosis (RME)
is a process by which cells absorb metabolites, hormones, other proteins – and in some cases viruses – by the inward budding of plasma membrane vesicles containing proteins with receptor sites specific to the molecules being absorbed (endocytosis).
Receptor-mediated endocytosis (RME)
a molecule that binds to another (usually larger) molecule.
LIGAND
Receptor-mediated endocytosis was discovered by——— and ———-, who were investigating the internalization of cholesterol by cells from the bloodstream.
Michael Brown
Joseph Goldstein
What did Micheal Brown and Joseph Goldstein discover?
Receptor-mediated endocytosis
Brown and Goldstein won the Nobel Prize in medicine in ——— for their discovery.
1985
———, a type of lipid , is insoluble and is transported in the bloodstream bound to protein in particles called low density lipoproteins (LDL).
Cholesterol
Cholesterol, a type of lipid , is insoluble and is transported in the bloodstream bound to protein in particles called.
low density lipoproteins (LDL)
allows cells to take up specific macromolecules called ligands, such as proteins that bind insulin (a hormone), transferrin (an iron-binding protein), or low-density lipoprotein cholesterol carriers.
RME
requires specific membrane receptors that recognize a particular ligand and bind to it.
RME
Process by which cells release particles from within the cell into the extracellular space.
Exocytosis
is a vital process that allows cells to secrete waste substances, as well as molecules such as hormones and proteins.
Exocytosis
It is also the method used to build up and incorporate lipids and proteins into the cell membrane.
Exocytosis
Importance of Exocytosis:
- Constitutive Exocytosis
- Regulated Exocytosis
- Involvement of lysosomes
Involves the regular secretion of molecules that is performed by all cells.
Constitutive exocytosis
Relies on the presence of extracellular signals for the expulsion of materials within vesicles.
Regulated exocytosis