Brucella Flashcards

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1
Q

Basic Characteristics (2)

A

Gram-Negative

Coccobacilli

(Non-capsulated, Non-motile, Nom-sporing)

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2
Q

How to cultivate?

A

Blood agar (Enriched media) in 5-10% CO2

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3
Q

Transmission

A

Zoonotic

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4
Q

Clinical Features (3)

A

Flu-like illness

Undulant fever —> rises and falls (Mediterranean Fever or Malta Fever)

Multisystem involvement —> Granuloma or Abscess

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5
Q

Virulence

A

INTRACELLULAR bacterium —> survives inside PHAGOCYTE by BLOCKING MYELOPEROXIDASE system

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6
Q

Where do they multiply inside the cell?

A

Endoplasmic Reticulum

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7
Q

What is the Two-component regulatory system that controls Intracellular multiplication?

A

1- BvrR/BvrS

2- Type IV secretion —> VirB —> secretes virulence proteins into host cell

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8
Q

Which types are virulent?

A

With smooth lipopolysaccharides (LPS)

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9
Q

Routes of entry

A

1- Ingestion (unpasteurized milk, cheese, butter, ice cream, contaminated meat)

2- Aerosol

3- Contact with broken skin

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10
Q

Who is at greater risk?

A

Humans in contact with animals (farm workers, vets, abattoir workers)

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11
Q

Human-to-human spread?

A

No

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12
Q

How to control infection? (2)

A

Vaccination of Animals

1- Cattle —> Live B.abortus vaccine

2- Goat —> Live B.melitensis Rev1 vaccine

Slaughtering of infected animals

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13
Q

B.abortus

A

Cattle

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14
Q

B. melitensis

A

Sheep, goats, camels (most common)

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15
Q

B.suis

A

Pigs

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16
Q

B.canis

A

Dogs