Broncho/Laryngospasm-Pneumo-AirwayFire Flashcards
Differential diagnoses for s/s associated with bronchospasm:
- obstructed ETT
- light anesthesia
- pneumo
- aspiration
- R mainstem
- anaphylaxis
- medication
Pathphys of bronchospasm:
reflexive bronchiolar constriction (either centrally mediated OR local airway irritation)
Common causes of bronchospasm:
- anaphylactoid drug rxn
- blood trf rxn
- histamine releasing drugs
- smokers
- chronic bronchitis/COPD
- light anesthesia
- noxious stimuli (secretions, intubation, ETT manipulation)
3 compounds mediating bronchoconstriction
1) IP3
2) phospholipase C
3) leukotrienes
Process of bronchoconstriction:
1) airway innervated by PNS (vagus nerve (X))
2) ACh hits M3 receptors
3) activates phospholipase C
4) activates IP3 (2nd msgr)
5) stimulates Ca2+ release
6) smooth muscle contraction/bronchoconstriction
Compounds mediating bronchodilation:
- cAMP
- cGMP
- NO
- vasoactive intestinal peptide
Process of bronchodilation
1) no SNS innervation
2) B2 activated by Epi/NE
3) Gprotein coupled receptor > adenylate cyclase > increase cAMP
4) cAMP (+ phospkinase A) decrease Ca2+ release
5) decreased smooth muscle contraction / bronchodilation
MOA of NO on bronchodilation
- non-cholinergic PNS nerves release vasoactive intestinal peptide into airway smooth muscle > NO production > cGMP stimulation > airway relaxation
Symptoms of bronchspasm
- reduced SaO2
- shark fin capnography waveform
- wheezing
- increased airway resistance (PIP)
- decreased exp flow rate
Hallmark symptom of both awake and anesthetized patients experiencing bronchospasm
wheezing
worse on expiration
Decreased expiratory flow rates leads to…
- air trapping
- increased intrathoracic pressure
- decreased VR, CO, BP
- Auto-PEEP
Treatment for bronchospasm:
- 100% O2
- confirm ETT position
- deepen anesthetic
- inhaled B2 agonist/anti-muscarinic
- bronchodilators
- steroids
Possible bronchodilators used to treat bronchospasm
- volatile agents
- Epi 1-10mcg/kg bolus
- Ketamine 0.2-1mg/kg
- Mg
Describe steroid use in bronchospasm
- Hydrocortisone 100mg IV
- not helpful in acute phase
- won’t reverse acute bronchospasm
- used for LT airway irritation
Methods for prevention of bronchospasm
- avoid airway manipulation in at-risk pts (URI, smoker, asthma exacerb)
- bronchodilators on induct/emerg
- regional
- deepen prior to intubation
- deep extubation
- monitor P-V loops (early detection)
Complications of bronchospasm
- hypoxemia
- hypercarbia
- HoTN
- arrhythmias
Tx for Auto-PEEP
- disconnect ETT x5-10 sec
- decrease RR, Vt, inspiratory time
How is Auto-PEEP recognized on ventilator
failure of expiratory waveform to return to zero baseline before next inspiration
Vagus nerve forms 2 important branches:
- superior laryngeal nerve
- recurrent laryngeal nerve
Superior laryngeal nerve EXTERNAL branch provides…
motor innervation to the cricothyroid muscle (tenses vocal cords)
Superior laryngeal nerve INTERNAL branch provides…
sensory innervation to the larynx between epiglottis and including vocal cords
Recurrent laryngeal nerve provides…
motor innervation to all muscles EXCEPT cricothyroid
AND
sensory innervation to the larynx below the vocal cords & trachea
SCAR pneumonic for motor innervation
Superior laryngeal nerve ext branch
Cricothyroid muscle
All other muscles
Recurrent laryngeal nerve