broken lady bits Flashcards
congenital ut anomalies aka __
müllerian duct anomalies
what happens if there is failure of mullerian duct organogenesis
one or both ducts underdevelop
result of bilaterally underdeveloped organogenesis
uterine agenesis or hypoplasia
result of unilateral failure of organogenesis
unicornuate ut
what is the result of failure of fusion step of mullerian duct development
bicornuate or didelphys ut
most congenital malformations are due to incomplete fusion of the __
ureterogenital primordium (ut and upper vagina)
lower segments of mullerian ducts fuse to form __
ut, cx, and upper vagina
what is the result of failure of septal resorption step of mullerian duct development
septate ut
what are the 6 I’s (causes of congenital ut anomalies)
idiopathic
inherited
intrauterine infections
ionizing radiation
ingestion of drugs
in utero exposure to DES
what does DES stand for
diethylstilbestrol
there is a greater incidence of congenital ut anomalies among pts that are __
infertile
what is most common association with congenital ut anomalies
unilateral renal agenesis
what is the rate of congenital ut anomaly with unilat renal agenesis
55-75%
what is rate of renal anomalies when there is a case of congenital ut anomaly
20-30%
which congenital ut anomaly is associated with the highest incident of renal anomalies (nearly 50%)
unicornuate ut
renal tissue cannot develop without __
ureteric bud
renal agenesis occurs due to a failure of __
ureteric bud to form from distal end of Wolffian
what constitutes a recurrent abortion
> /= 3 losses in a row
what is the most accurate imaging modality for ut anomalies
MRI
what is likely the ut anomaly when seeing a blind ended vagina
uterine agenesis
does a unicornuate ut have fallopian tube
yes
unilateral mullerian duct agenesis results in __
unicornuate ut
incomplete development of one mullerian duct results in the formation of a __
rudimentary horn
how many ovaries does a unicornuate ut have
2
develop independently
which side is most common for rudimentary horn
right
two types of rudimentary horns
non obstructed (soft tissue iso mass)
obstructed (functioning endo)
double ut aka
didelphys
didelphys due to near complete failure of __
fusion
can you see a vaginal septum on u/s
very difficult unless obstructed
name of congenital anomaly with 2 separate, symmetrical ut bodies
uterus didelphys
didelphys associated with infertility T/F
false- if anything, 2x chance lol
bicornuate ut aka
bicornis
name of congenital anomaly where incomplete fusion of ut at level of the body/fundus
bicornuate
name of congenital anomaly with 2 cornu and 2 cervices
bicornuate bicollis
name of congenital anomaly with 2 cornu and 1 cervix
bicornuate unicollis
bicornuate fundal cleft __ cm sonographic to distinguish heart shape from septate
> 1 cm
coronal EV most reliable plane of section
__ required to make final diagnosis of bicornuate ut
MRI and physical exam
otherwise hard to delineate 1 or 2 cervices
what is the reproductive outcome of bicornuate uterus
highest rate of incompetent cervix
name of congenital anomaly with partial or complete failure of septum resorption after mullerian duct fusion
septate uterus
septate ut aka
uterus septus
failure of resorption
what are the two types of septate ut
septate (septum extends to internal os)
subseptate (partial)
which is the most common congenital ut anomaly
subseptate uterus (partial septum)
what is the distinguishing feature of septate vs bicornuate ut
septate <1cm concave fundal contour
bicornuate >1cm convex heart shape fundus
in septate ut, the septum is composed of __
poorly vascularized fibromuscular tissue
reproductive outcome of septate ut
poor
abnormal fetal lie and presentation
postpartum bleeding and secondary RPOC
reproductive outcome of unicornuate ut
related to infertility and pregnancy loss
is differentiating septate v. bicornuate important? why?
tx is different
septate requires hysteroscopic resection of ut
name of congenital anomaly with saddle-like defect to fundal ut cavity
arcuate ut
normal serosal contour
arcuate ut is arguably a __
normal variant
reproductive outcome of arcuate ut
slight risk of spontaneous abortion and premature labour
what is the rate of ut anomaly to female fetuses exposed to DES in utero
66%
what are the complications with DES daughters
congenital anomalies of repro tract
clear cell adenocarcinoma of upper vagina
what would you expect to see with a DES daughter’s pelvic scan
small, T shaped endo cavity
small ut (hypoplasia)
ut constriction rings (aka narrowing stenoses)
what is the gold standard for assessing DES malformation
MRI
reproductive outcome of DES malformation
ectopic (due to abnormal fallopian tubes)
spontaneous abortion
premature labour (cervical incompetence)
term for accumulation of blood in ut and vagina
hematometrocolpos
vaginal septum has __ origin
mullerian origin
usually related to cranial vagina
vaginal septum most commonly associated with __
ut didelphys
open or closed vaginal septum associated with ut didelphys is called a
longitudinal septum
a closed vaginal septum resulting in hematocolpos or hematometrocolpos with primary amenorrhea is referred to as
a transverse septum
__ covers and obstructs the vaginal canal
imperforate hymen
imperforate hymen mimics __ but is not a mullerian defect
low transverse septum
what is a mechanical cause of primary amenorrhea
imperforate hymen
NSA, adolescent with cyclic pelciv pain lasting several days (pubertal age) with primary amenorrhea likely experiencing
imperforate hymen
term for vaginal agenesis and uterine hypoplasia/agenesis
MRKH
MRKH stands for
Mayer-Rokitansky-Kuster-Hauser syndrome
cause of MRKH
unknown
normal external genitalia, ovaries, and tubes
what is likely happening to a pt with blood distended ut and absent vagina
MRKH syndrome
what is the average size of hydatid cyst of morgagni
<1cm
often too small to see with u/s
simple paraovarian cyst separate from ovary
gartner duct cysts potential remnants of __
wolffian ducts
mucus-filled cysts within myometrium are called
nabothian cysts
nabothian cysts aka
blocked glands
what is the ddx for a gartner duct cyst
Bartholin gland cyst
term for new but abnormal growth of a tumour
neoplasm
is a neoplasm benign or maignant
can be either
an abnormal increase in no. of normal cells
hyperplasia
an abnormal increase in the size of normal cells
hypertrophy
term for the inability to conceive within 12 months of regular attempts
infertility
a woman >/= 35 y is considered infertile if unsuccessful when trying for __ months
6
rates of primary infertility have __ in the last 20 y
increased
term for the inability to conceive or maintain a pregnancy after having been successful at least once
secondary infertility
what are the risk factors for infertility
age
smoking/alcohol use
over/underweight
excessive exercise
caffeine
PID
endometriosis
causes of infertility
inability for:
production of oocytes
oocytes meeting
implantation
carrying to viability
what is the rate of male factor in infertility
40%
what is the most common cause of female factor infertility
tubal disease
(secondary to PID, endometriosis, previous ectopic)
female causes of infertility
tubal disease
ovarian dysfunction
cervical factor
ut abnormalities (myomas, septate congenital, etc)
how do you dx DES malformation
hestersalpingography
increased risk of __ of vagina, infertility, spontaneous abortion and preterm delivery with DES malformation
clear cell adenocarcinoma of the vagina
infertility due to presence of synechiae (+/- calcifications)
Asherman syndrome
Asherman syndrome presents secondary to __
scarring from trauma or sx
ie. D&C
3 important tests for infertility in female
tubal patency
uterine disease
assessment of ovarian reserve
a decline in no. of follicles and oocyte quality is a diminished __
ovarian reserve
ART stands for
assistive reproductive therapy
what role does u/s have in ART
ovarian follicle count for reserve assessment
the timed hormonal injections which stimulate follicular development and ovulation is called
ovarian hyperstimulation therapy
ovarian hyperstimulation therapy may cause __
OHSS (ovarian hyperstimulation syndrome)
common signs of OHSS are
theca lutein cysts
pelvic pain
abdominal distention
common OHST drugs
clomephene citrate (Clomid, Serophene) -> stimulates pituitary
human menopausal gonadotropin (Perganol, Repronex) -> stimulates ovary directly
diameter of follicle with OHST pre ovulation
~20mm
+/- cumulus oophorus
OHSS most commonly occurs with which rx
pergonal and reprones (hMG)
IVF stands for
in vitro fertilization
IUI stands for
intrauterine insemination
GIFT stands for
gamete intrafallopian transfer
ZIFT stands for
zygote intrafallopian transfer
ICSI stands for
intracytoplasmic sperm injection
what is the most common ART technology used
IVF
ovum and sperm combined in a dish, resultant zygote transferred to ut at blastocyst stage
IVF
~5 days after conception
pregnancy rate of IVF
30-40%
live birth rate of IVF largely depends on __
age of pt
<35 y 32%
>40 y 12%
parameters positively affecting pregnancy rate is presence/absence/direction of __
subendometrial myometrial contractions
**dr. lyons publication
retrograde motion (cx to fund) at peak incidence during preovulatory period
heterotopic pregnancy incidence increased with __
IVF
frozen sperm inserted directly into the ut
IUI
used with male factor infertility
laparoscope used to insert ovum and sperm directly into fallopian tube
GIFT
used for cervical factor and unexplained infertility
GIFT requires a normal __
fallopian tube
2 step procedure
1 - ovum fertilized in lab dish
2 - transfer to fallopian tube
ZIFT
transfer of zygote
most invasive
single sperm injected into ovum and returned to ut in ~5 days is
ICSI
transfer of blastocyst
used for severe male factor infertility or repeated failed IVF
abnormal development, growth or differentiation of cells is
dysplasia
adnexal masses are most commonly __
ovarian
ovarian masses are most commonly __
cystic
large ovarian masses can cause __
hydronephrosis
bilateral ovarian dysgenesis aka
streak ovaries
streak ovaries primarily associated with __
Turner syndrome
what chromosomal abnormality is 45x0
turner syndrome
absence of all or part of one x chromosome is
turner syndrome
characteristics of person with turner syndrome
short stature
absence of secondary sexual characteristics
infantile genetalia
streak ovaries
hypoplastic ovaries with nonfunctional tissue called
streak ovaries
streak ovaries are a result of hormonal disruption;
__ EST, __ FSH, __ LH
low est
high fsh
high lh
additional ovaries that develop separate from normal ovary called
supernumerary ovaries
additional ovary that is attached to an ovary is called
accessory ovary
*functional
what is the most common cause of palpable adnexal masses in young adult females of reproductive age
non neoplastic ovarian pathology
sonographic detection and characterization of ovarian pathology is __ acurate
highly
what differentiates a normal follicle from a follicular cyst
> 2.5 cm
will not ovulate or rupture
follicular cyst should regress spontaneously within __
3 months
follicular cysts may secrete __
estrogen
can cause menstrual disturbance
what is the difference between a CL and a CL cyst
CL cyst is persistent
*failure of resorption
*bleeding into CL
CL cyst may secrete __
progesterone
normal CL secretes __
prog and est
normal CL stimulated by __ that triggered ovulation
LH surge
CL cyst often associated with
missed or delayed periods
CL cysts are usually __ in size
3-5 cm
CL cyst of pregnancy secretes __
this secretion is taken over by placenta after __ GA and CL resolves
progesterone
12w GA
what is difference between corpus albicans and corpus albicans CYST
trick q. unable to ddx from CL
but no hormonal activity
a cyst into which there has been bleeding
hemorrhagic
the 2 most common types of hemorrhagic cysts
corpus hemorrhagicum (CL)
endometrioma
most patients with hemorrhagic cysts relay what clinical signs
acute, onset lower abd pain
what is the evolution of a hemorrhagic cyst
1 - acute hemorrhage
2 - clot formation
3 - clot retraction
sonographic appearance of early hemorrhagic cyst
blood is echogenic as it clots
*various appearances of mixed, diffuse and fibrin mesh
sonographic appearance of late stage hemorrhagic cyst
decreasing echogenicity as the clot lyses
what is the vascularity of a hemorrhagic cyst
avascular
can be flow in wall
what are the 2 forms of endometriosis
diffuse
localized (endometrioma)
which type of endometriosis is more common
diffuse
endo implants throughout peritoneum
endometrioma aka
chocolate cyst
what is the relationship of endometrioma to hormones
does not secrete
is affected by cyclic est and prog levels (cyclic bleeding)
clinical hx with endometriosis
+/- dysmenorrhea
+/- dyspareunia
+/- infertility
what is the slam dunk characteristic of endometrioma
calcifications in cyst wall
what can happen to endometriomas within pregnant pts
decidualization of the wall
results in solid, VASCULAR mural mass that CANNOT be ddx from malignancy
what causes theca lutein cysts
hyperstimulated ovaries (hCG) -abnormal pregnancy (GTD, hydrops, multiples)
-normal pregnancy (rare)
- ART
or oversensitive ovaries
theca lutein cysts regress when __ is removed
hormonal stimulus
in normal ovary, __ line the functional cysts
theca cells
would you expect to see ascites with theca lutein cysts
no
theca lutein cysts are always __
bilateral
theca lutein cysts occurring with a normal IUP and normal levels of hCG is referred to as
hyperreactio luteinalis
ovaries are just really sensitive to hCG
term for small, simple cyst in or on a post-menopausal ovary
serous inclusion cyst
what is the typical size of a serous inclusion cyst
<2.5-3cm
how do you distinguish a serous inclusion cyst from an ovarian or paraovarian cyst
you cannot
what is the speculated cause of a serous inclusion cyst
cyst pinched off from indentations in the surface epithelium of the ovary
no hormonal activity
what is the alternate name for PCOS
Setin-Leventhal syndrome (SLS)
what type of hormonal disorder is PCOS
endocrine
metabolic
**not an ovarian disease
what is the most common hormonal disorder among females of reproductive age
PCOS
PCOS associated with chronic __ due to hormonal imbalance
anovulation
clinical features of PCOS
amenorrhea
hirsutism
obesity
+/- infertility
+/- serum androgens
high LH
normal to low FSH
ratio results in ++ androgens in ratio
causes of PCOS
excess insulin
heredity
exposure to ++ androgen as fetus
low grade inflammation (insulin resistance and cholesterol accumulation)
risks from PCOS
endometrial hyperplasia (due to chronic hyperestrogenism)
DM2
cardiovascular/cerebrovascular disease. (increased lipids)
diagnosis of PCOS
clinical and chemical
**need hormonal assays to confirm
what ‘sign’ is associated with PCOS
‘string of pearls’
what sono ‘sign’ is seen with theca lutein cysts
‘soap bubble’
‘spoke wheel’
sonographic features of serial ultrasounds in positive PCOS case
lack of follicular development
lack of dominant follicle
no change to thickened endometrium
what is usual cause of ovarian torsion
enlarged ovary due to a mass
ovarian torsion is the twisting of the __
vascular pedicle
which ligaments are involved with ovarian torsion
ovarian ligament
infundibulopelvic ligament
clinical features of ovarian torsion
acute onset lower abdominal pain
one side more painful than contralateral
**may be mistaken for appendicitis if on RT
with torsion, ovary may swell to the point of __
rupture
sonographic features of ovarian torsion
enlarged, hypoechoic ovary
tender with pressure
+/- cyst; thick walls!!
+/- FF in PCDS
decreased or absent flow
** blood flow may be seen due to anastomosis between ovarian and uterine arteries
sonographic feature of twisted vascular pedicle
‘whirlpool’ sign
sono feature of ovarian torsion with hemorrhage or infarction
cystic or complex adnexal mass with fluid debris level or septa
what masses may have echogenic foci
dermoid cysts
inclusion cysts
endometriomas
psammoma bodies
what are psammoma bodies
sand-like calcifications in serous cystadenocarcinomas
name for development of an ovarian cyst after oopherectomy
ovarian remnant syndrome
likely due to a small portion of ovary not being resected
ovarian remnant syndrome clinical sign
chronic pelvic pain
usually happens with patients that had a lot of adhesions at time of sx
sono features of ruptured ovarian cyst
u/s may be normal
cyst may still be present
+/- FF
**echogenic FF requires ruling out an ectopic pregnancy if pt of reproductive age
the majority of malignant ovarian neoplasms occur in __ menopausal patients
post menopausal
what are the subtypes of ovarian neoplasms
epithelial
germ cell
stromal
metastatic
__ neoplasms originate in tissue that surrounds the ovary
epithelial
accounts for 90% of cases
__ neoplasms original in the cells that produce eggs
germ cell
__ neoplasms originates in the tissues that hold ovaries together and hormone producing tissues
stromal
what are the 2 most common types of ovarian neoplasms
cystic teratoma (dermoid)
serous cystadenoma
what are the 3 types of epithelial tumours
adenoma
carcinoma
adenocarcinoma
benign epithelial neoplasm from glandular cells
adenoma
malignant epithelial neoplasm
carcinoma
malignant epithelial neoplasm derived from glandular cells
adenocarcinoma
of, resembling or producing serous fluid
serous tumour
epithelial
of, relating to or covered with mucus
mucinous tumour
epithelial
which is more common - serous or mucinous epithelial tumours
serous
which is typically larger - serous or mucinous epithelial tumours
mucinous
cystadenomas and cystadenocarcinomas can be __
serous or mucinous
pre or post menopause
what is the single most common ovarian epithelial tumour
serous cystadenoma
clinical symptoms of cystadenomas and cystadenocarcinomas
few, if any symptoms
increasing abdominal girth
occasional pain (hemorrhage, torsion, infection)
menstrual disturbance (uncommon)