Breast Lumps Flashcards

1
Q

Breast lump assessment

A

Triple assessment:

1) Clinical examination
2) Radiology
3) Histology / Cytology

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2
Q

Radiological assessment for breast lumps

A

< 35 yrs USS

> 35 yrs USS + mammogram

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3
Q

Modes of cytology for breast lump assessment

A

Core biopsy or Fine needle aspiration

+/- Sentinel node biopsy

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4
Q

Role of sentinel node biopsy

A

Reduces unnecessary axillary lymph node clearance

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5
Q

Breast cyst definition

A

Benign
Fluid filled
Mobile

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6
Q

Breast cyst epidemiology

A

Common > 35 yrs

esp Peri-menopausal

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7
Q

Mastitis / Breast abscess definition

A

Infection of mammary duct

Associated with lactation

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8
Q

Most common cause of mastitis

A

Staph aureus

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9
Q

Sx of breast abscess

A

Painful, hot swelling of breast segment

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10
Q

Mx of breast abscess

A

Abx / drainage

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11
Q

Mx of mastitis

A

Abx if:
Milk culture positive
Open infected nipple fissure
Failure to improve with 24hrs effective milk removal

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12
Q

Abx for mastitis

A

Flucloxacillin

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13
Q

Duct ectasia definition

A

Around menopause
Ducts become blocked
Secretions stagnate

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14
Q

Sx of duct ectasia

A

Nipple discharge
Green/brown/bloody

+/- nipple retraction or lump

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15
Q

Mx of duct ectasia

A

Usually none required

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16
Q

Fat necrosis definition

A

Lump following breast tissue injury
Fibrosis + calcification post injury
No Rx needed

17
Q

Fibroademona definition

A

Benign overgrowth of collagenous mesenchyme of one breast lobule

18
Q

Fibroadenoma age of presentation

A

Usually < 30 yrs

19
Q

Sx of fibroadenoma

A

Firm
Smooth
Mobile
Painless

20
Q

Mx of fibroadenoma

A

Observation and reassurance

Surgical excision if large

21
Q

Biochemical cause of gynaecomastia

A

Raised oestrogen/androgen ratio

22
Q

Causes of gynaecomastia

A
Hypogonadism
Liver cirrhosis
Hyperthyroidism
Tumours
Drugs
23
Q

Drug causes of gynaecomastia

A

Oestrogen
Spironolactone
Digoxin

24
Q

Paget’s disease of the breast

A

Intra-epidermal spread of an intraduct cancer

25
Sx of Paget's disease of breast
Any red scaly lesion of nipple - must biopsy | Looks like eczema
26
Mx of Paget's disease of breast
Breast conserving surgery + Radiotherapy + Sentinel node biopsy
27
Tamoxifen
ER antagonist | Hormonal therapy for ER positive tumours
28
Anastrozole
Aromatase inhibitor Post-menopausal hormonal therapy for ER positive tumours Targets peripheral E2 synthesis
29
Generic name for Herceptin
Traztuzumab
30
Traztuzumab
For HER2 positive tumours
31
Goserelin
GnRH analogue If premenopausal + ER positive Shrink tumour prior to surgery