Breast Cancer Flashcards
RFs for breast cancer
FH Age Unopposed E2 Genetics Previous cancer
Genetic RFs for breast cancer
BRCA1 (chromosome 17)
BRCA2 (chromosome 13)
Factors increasing unopposed E2
Early menarche / Late menopause Obesity HRT Nulliparous Liver cirrhosis
Protective factors against breast cancer
Breastfeeding
Types of breast cancer
1) Invasive ductal carcinoma
2) Invasive lobular carcinoma
3) Non invasive ductal carcinoma in situ
4) Non invasive lobular carcinoma in situ
5) Medullary cancer
6) Colloid / Mucoid
7) Phyllodes tumour
Ix for breast lumps
Triple assessment
Ductal carcinoma in situ (DCIS) mammogram features
Microcalcification
Pre-malignant
Most common type of breast cancer
Invasive ductal carcinoma
Features of invasive ductal carcinoma
Feels firm
Features of medullary cancer
Younger people
Feels soft
Features of colloid / mucoid cancers
Elderly people
Features of phyllodes tumour
Stromal tumour
Large
Non tender
Mobile
Methods of breast cancer spread
Direct spread to muscle/skin
Lymphatic
Blood
Sign of lymphatic spread
Peau d’orange
Common metastasis sites of breast cancer
Bone
Lung
Liver
Brain