Breast Cancer Drugs

Question 1

Tamoxifen, Reloxifene

Answer 1

Class: SERMS
Mechanism: competitive estrogen receptor antagonist
Use: ER+ breast cancers
SE: hot flushes, nausea/vomiting. INCREASED RISK ENDOMETRIAL CANCER

Question 2

Anastrozole

Answer 2

Class: Aromatase inhibitor
MEchanism: prevents estrogen synthesis from androgens (androstenedione/testosterone)
SE: Hot flashes, nausea/vomiting, fracture risk