Breast Cancer (DCIS + LCIS)

Question 1

Whats is the general term given to a DCIS + LCIS

Answer 1

Early form of breast cancer that has not developed the ability to spread within / outside of the breast

Lobular => Lobules
Ductal => Ducts

Question 2

What are DCIS / LCIS linked with

Answer 2

high oestrogen exposure

Question 3

Do DCIS / LCIS have cancer?

Answer 3

No

But Px are at a higher risk of developing breast cancer

Question 4

What is the odds of DCIS / LCIS developing into cancer

Answer 4

1/9 women

Question 5

What are 4 risk factors of developing DCIS / LCIS

Answer 5

HRT

Obesity + Alcohol

BRCA1 + 2 (5-10%)

Early Menarche (around 12)

Question 6

what are the 2 general changes to the breast that happen in DCIS / LCIS

Answer 6

Gross breast changes => Size / shape / apperance

Nipple changes => Peeling / crusting / flaking / discharge

Question 7

What is the investigations of a DCIS / LCIS (2)

Answer 7

Mammograms / Ultrasounds ==> Calcifications

Sentinel Lymph Node Biopsy (SLNB)

Question 8

What are the surgical treatments for DCIS / LCIS (2)

Answer 8

Lumpectomy

Partial / Full Mastectomy

Question 9

What are 4 therapies outside of Surgery that can be done fo DCIS / LCIS

Answer 9

Radiotherapy

Chemotherapy

Hormone Therapy

Monoclonal Therapy

Question 10

What hormonal therapy is given to premenopausal women

Answer 10

Tamoxifen => Blocks oestrogen to cancer

Question 11

What hormonal therapy is given to postmenopausal women

Answer 11

Aromatase inhibitors (Letrozole) => Stops production of oestrogen

Question 12

What type of monoclonal AB is given in DCIS / LCIS

Answer 12

Trastuzumab (Herceptin) => Stops growth of cancer