Breast CA med

Question 1

Herceptin

Answer 1

transtuzumab
HEr 2 (+) metastatic
flu-like sx, serious infusion reaction,
cardiotoxicity, pulmonary toxicity

Question 2

Perjeta

Answer 2

Pertuzumab
HEr 2 (+) metastatic --combine or after Herceptin

Question 3

Kadcyla

Answer 3

Ado-trnstuzumab
HEr 2 (+) metastatic; cardiotoxicity, pulmonary toxicity, embryo-fetal toxicity

Question 4

Ixempra

Answer 4

Ixabepilone
tumors are resistants to anthracyclines, taxanes and capecitabine
“just like Paclitaxel”-alcohol, castro oil
pretreat w/ H1 and H2 blockers b4 infusion, steroids if hypersensititvity

Question 5

Halaven

Answer 5

Eribulin mesylate

microtuble inhi; for pt with metastatic breast CA who rec at least 2 pior chemo 4 late stage

Question 6

Fulvestrant

Answer 6

Faslodex
Estrogen receptor antagonist
bleeding, thrombocytopenia, SE (site pain, GI, bone pain, back pain, hot flash, anorexia, musculoskeletal pain

Question 7

Megace

Answer 7

Megestrol
for advanced breast or endometrial CA; stimulate appepite (incr progestin–> hungry)
SE: wt gain, thromboembolism