Breast Ca Flashcards
1
Q
BRCA 1 prophylaxis / screening
A
annual breast MRI from 30-50
mastectomy greatest benefit when done <40
BSO by 35
2
Q
BRCA 2 risk management
A
annual breast MRI from 30-50, mastectomy greatest benefit when done <40
BSO by age 45
3
Q
Tamoxifen risks
A
VTE, endometrial ca, hot flushes
is bone protective$$$$$
4
Q
Aromatase inhibitors risk
A
hot flushes, myalgia, osteoporosis, mood changes
5
Q
GnRH agonist precautions
A
dont use in IHD as increases risk
give bicalutamide for first 4 weeks of therapy
6
Q
What is abiraterone and what are the precautions
A
It inhibits CYP 17A1
Prevents testosterone synthesis
needs to be given with prednisolone to prevent pseudo-Conn’s syndrome
7
Q
What cancer is poiglitazone associated with?
A
urothelial carcinoma
