Breast Flashcards

1
Q

What is the assessment of breast lumps?

A

Tripple assessment
Clinical examination
Imaging - Us or mammography
Histology - fine needle or core biopsy

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2
Q

Red flag signs of breast cancer

A

Lumps that are hard, irregular, painless or fixed in place
Lumps may be tehtered to the skin or chest wall
Nipple retraction - unilateral nipple changes
Skin dimpling - or oedema (peau d’orange)

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3
Q

Define fibroadenoma

A

Common bengn tumours of stromal/epithelial breast duct tissue. More common in younger womesn

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4
Q

Clinical signs of fibroadenoma

A

Painless
Smooth
Round
Well circumscribed mass
Firm
Mobile
3cm diameter

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5
Q

Define fibrocystic breast changes

A

Generalised lumpiness to the breast, is considered a variation of normal and not a disease. Connective tissues respond to oestrogen and progesterone becoming fibrous and cystic.

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6
Q

Clinical signs of fibrocystic breast changes

A

Lumpiness
Breast pain or tenderness
Fluctuating breast size..

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7
Q

Management of fibrocystic breast changes

A

Supportive bra
NSAIDs
Avoid caffeine
Apply heat
Hptmonal treatment

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8
Q

Define breast cysts

A

Benign individual fluid filled lumps. Most common cause of breast lumps and occur most often between ages 30 and 50.

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9
Q

Clinical signs of breast cysts

A

Smooth
Well circumscribed
Mobile
Possibly fluctuant

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10
Q

Define fat necrosis of breast

A

Causes a benign lump by localised degeneration and scaring of fat tissue in the breast. Often caused by trauma, radiotherapy or surgery.

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11
Q

Clinical signs of fat necrosis in breasts.

A

Painless
Firm
Irregular
Fixed in local structures
Skin dimpling or nipple inversion

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12
Q

Define lipoma

A

Benign tumours of fat tissue can occur anywhere including breasts.

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13
Q

Clinical signs of limpomas

A

Soft
Painless
Mobile
No skin changes

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14
Q

Define gynaecomastia

A

Refers to the enlargement of the glanduar breast tissue in males common in adolescents and older men.

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15
Q

Common causes of gynaecomastia

A

Hormone imbalance. Raised oestrogen.
Prolactin
Idiopathic
Obesity
Testicular cancer
Liver cirrhosis
Hyperthyroidism
hCG secreting tumour - SCLC
Reduction in testosterone - deficiency, hypothalamic pituitary issues, klinefelter, orchitis
Steroids, antipsychotics, digoxin, spirinolaction, GnRH agonist, opiates

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16
Q

Define mamary duct ectasia

A

Benign condition where there is dilation of the large ducts in the breasts. Inflammation of the ducts leads to nipple discharge - often grey/white. Occurs perimenopausaly in smokers

17
Q

History of mammary duct ectasia

A

Nipple discharge
Tenderness or pain
Nipple retraction
Breast lump

18
Q

Managemment of mammary duct ectasia

A

Reassurance
Symptomatic management of mastalgia
Abx if infection
Surgical excision

19
Q

Define intraductal papiloma

A

Warty lesion that grows within on of the ducts of the breast. Causes clear or blood stained nipple discharge.

20
Q

History of intraductal papiloma

A

35-55
Asymptomatic - identified on mammogram
Nipple discharge - clear or blood stained
Tenderness or pain
Palpable lump

21
Q

Management of intraductal papiloma

A

Complete surgical excision + further examination of lump for cancer

22
Q

Define lactational mastitis

A

Inflammation of breast tissue as a complication of breastfeeding. CAn be caused by obstruction or infection.

23
Q

History of lactational mastitis

A

Breast pain, or tenderness
Erythema in a focal area
Local warmth and inflammation
Nipple discharge
Fecer

24
Q

Management of lactational mastitis

A

Blockage - conservative, continue breasfeeding/expressing milk, heat packs and analgesia
Infection - abx (flucloxacillin) or sample and cultre breast milk. Encourage breastfeeding/expression

25
Define breast abscess
Collection of pus within an area of the breast Can be lactational or non-lactational
26
History of breast abscess
Mastitis with infection Nipple changes Purulent nipple discharge Localised pain Warmth Erythema Hardening of the skin or breast Swelling Generalised systemic symptoms Swollen fluctuant tender lump.
27
Management of breast abscess
Abx US Drainage Microscopy
28
Risk factors for breast cancer
Female Increased oestrogen exposure - early onset periods, late menopause Dense breast tissue Obesity Smoking FH COCP HRT (combined!)
29
What genes are associated with breast cancer
BRACA1 and 2 TP53 and PTEN
30
What are some common types of breast cancer
Ductal Carcinoma in Situ (DCIS) Lobular carcinoma in situ (LCIS) Invasive ductal cardinoma (NST no specific type) Invasive lobular carcinoma (ILC) Inflammatory breast cancer Medullary Mucinous Tubular
31
What is Paget's disease of the nipple
looks like eczema of the nipple Erythematous scaly rash Indicates breast cancer involving nipple
32
Red flags for breast cancer
Lumps that are hard, irregular, painless or fixed Nipple retraction Skin dimpling or oedema (peau d'orange) Lymphadenopathy - axilla B symptoms
33
What type of lymph investigation is done in breast cancer
Sentinel lymph node biopsy
34
What are the main types of breast cancer receptors
Oestrogen Progesterone HER2
35
What are common sites of breast cancer metastasis
LLBB Lungs Liver Bones Brain