Brainstem Structure and Cranial Nerve Nuclei Flashcards
Brainstem Components (3):
- Midbrain
- Pons
- Medulla
What are the general areas of a brainstem cross section?
- The portion posterior to the ventricular space
- The portion anterior to the ventricular space
- Additional structures on the anterior surface

Brainstem Functions:
Integrative functions
- performed by a diffuse nucleus within the core of the brainstem
- reticular formation
Brainstem functions:
Reticular formation
- Helps regulate consciousness
- Respiratory & cardiovascular centers
What is the brainstem’s role for the sensory and motor tracts?
- Serves as a conduit for ascending sensory and descending motor tracts
-
Corticospinal tract
- voluntary movement of limbs
- Spinothalamic tract
- transmits sensory information
- pain and temperature
- Posterior column / Medial lemniscus system
- transmits sensory information
- touch, vibration, pressure and proprioception
Brainstem functions:
Cranial Nerves
- Cell bodies of neurons clustered in “nuclei” throughout the brainstem
- origins of motor CNs
- terminations of sensory CNs
- Nuclei are bilateral
- CN Nuclei are arranged in functional columns
Describe briefly how the nervous system develops:
- NS develops from neural tube
- Neural tube has basal plate (motor) and alar plate (sensory)
- divided by sulcus limitans
- Brainstem development is similar to spinal cord development
Brainstem Nuclei:
Somatic Motor (Red)
- Function
- Brainstem Nuclei ⇒ CNs

- Function: Innervate skeletal muscles in the head and neck that are derived from myotomes
- Oculomotor ⇒ CN III
- Trochlear ⇒ CN IV
- Abducens ⇒ CN VI
- Hypoglossal ⇒ CN XII
Brainstem Nuclei:
Branchial Motor (orange)
- Function
- Brainstem Nuclei ⇒ CNs

-
Function: Innervate skeletal muscles derived from branchial arches
- muscles of mastication, facial expression, pharynx, larynx, middle ear, trapezius m.
- Motor nucleus of V ⇒ CN V
- Facial nucleus ⇒ CN VII
- Nucleus ambiguus ⇒ CN IX and CN X
- Spinal Accessory nucleus ⇒ CN XI
- Located in spinal cord
Brainstem Nuclei:
Visceral Motor (Yellow)
- Function
- Brainstem nuclei ⇒ CNs

- Fucntion: Preganglionic parasympathetic innervation to cardiac m., smooth m. and glands
- Edinger-Westphal ⇒ CN III
- Salivatory ⇒ CN VII
- Inferior Salivatory ⇒ CN IX
- Dorsal motor nucleus of X ⇒ CN X
Brainstem Nuclei:
Visceral Sensory (Green)
- Function:
- Brainstem nuclei ⇒ CNs

-
Function:
- Special – Taste
- Rostral Nucleus solitarius (gustatory nucleus) ⇒ CN VII, IX and X
-
Function:
- General – Control of cardiorespiratory and digestive functions
- Caudal nucleus solitarius (cardiorespiratory nucleus) ⇒ CN IX & CN X
Brainstem Nuclei:
Somatic Sensory (Blue)
- Function:
- Brainstem nuclei ⇒ CNs

- Function: Convey touch, pain, temperature, position and vibration from skin, muscles and joints of the head
- Trigeminal nuclei ⇒ CN V, VII, IX and X
Brainstem Nuclei:
Special Sensory (Purple)
- Function:
- Brainstem nuclei ⇒ CNs

-
Function:
- Hearing
- Cochlear nucleus ⇒ CN VIII
-
Function:
- Balance
- Vestibular nuclei ⇒ CN VIII
Caudal Midbrain

- Cerebral aqueduct
- Raphe nuclei
- Trochlear nucleus
- Trochlear nerve fibers, on their way to the contralateral superior oblique
-
Inferior colliculus
- Site of termination of the lateral lemniscus and site of origin of the brachium of the inferior colliculus
- Lateral lemniscus ending in the inferior colliculus
- Anterolateral pathway
- Medial lemniscus
- Cerebral peduncle
- Substantia nigra
- Decussation of the superior cerebellar peduncles (DSCP)
- Pontine nuclei
- Central tegmental tract
- Medial longitudinal fasciculus (MLF)
- Mesencephalic trigeminal tract
- Periaqueductal gray
Rostral Midbrain (level of superior colliculus)


Midpons

- Fourth ventricle
- Medial longitudinal fasciculus (MLF)
- Superior cerebellar peduncle
- Anterior spinocerebellar tract
- Mesencephalic trigeminal tract and nucleus
- Trigeminal main sensory nucleus
- Trigeminal motor nucleus
- Anterolateral pathway
- Medial lemniscus
- Trigeminal nerve
- Pontocerebellar fibers
- from pontine nuclei of one side to the opposite middle cerebellar peduncle
- Corticospinal, corticobulbar, and corticopontine fibers from ipsilateral cerebral cortex
- Pontine nuclei
- Trapezoid body
- Central tegmental tract
- Superior olivary nucleus
- Lateral lemniscus
- Middle cerebellar peduncle
- Raphe nuclei
- Superior vestibular nucleus
- Inferior cerebellar peduncle entering the cerebellum
Caudal Pons

- Vermis of the cerebellum
- Fourth ventricle
- Medial longitudinal fasciculus (MLF)
- Raphe nuclei
- Abducens nucleus
- Superior cerebellar peduncle
- Inferior cerebellar peduncle entering the cerebellum
- Abducens nerve fibers, on their way to the ipsilateral lateral rectus
- Solitary tract and its nucleus
- Spinal trigeminal tract
- Spinal trigeminal nucleus (oral nucleus)
- Middle cerebellar peduncle
- Lateral lemniscus
- Anterolateral pathway
- Errant avian
- Corticospinal, corticobulbar, and corticopontine fibers, from ipsilateral cerebral cortex
- Pontocerebellar fibers
- Pontine nuclei
- Trapezoid body
- Medial lemniscus
- Central tegmental tract
- Superior olivary nucleus
- Facial motor nucleus
- Anterior spinocerebellar tract
- Facial nerve fibers
-
Lateral vestibular nucleus (VIII)
- source of the lateral vestibulospinal tract
- Juxtarestiform body
- Superior vestibular nucleus
- Internal genu of the facial nerve.
- Facial nerve fibers, most of them on their way to ipsilateral muscles of facial expression.
- Dentate nucleus
- Interposed nucleus
- Fastigial nucleus
Rostral Medulla

- Fourth ventricle
- Medial longitudinal fasciculus (MLF)
- Hypoglossal nucleus
- Dorsal motor nucleus of X
- Nucleus of the solitary tract
- Solitary tract
- Nucleus cuneatus
- Lateral cuneate nucleus
- Inferior cerebellar peduncle
- Posterior spinocerebellar tract entering the inferior cerebellar peduncle
- Location of nucleus ambiguus
- Anterolateral pathway
- Vagus nerve (CN X)
- Internal arcuate fibers
- Hypoglossal nerve fibers
- Pyramid
- Raphe nuclei
- Medial lemniscus
- Inferior olivary nucleus (medial accessory nucleus)
- Inferior olivary nucleus (principal nucleus)
- Fibers of the central tegmental tract reaching the inferior olivary nucleus
- Inferior olivary nucleus (dorsal accessory nucleus)
- Anterior spinocerebellar tract
- Spinal trigeminal tract
- Spinal trigeminal nucleus (interpolar nucleus)
- Inferior vestibular nucleus with bundles of vestibular primary afferents running through it
- Medial vestibular nucleus
Caudal Medulla

- Dorsal motor nucleus of X
- Nucleus gracilis
- Nucleus cuneatus
- Fasciculus cuneatus
- Lateral cuneate nucleus
- Spinal trigeminal nucleus (caudal nucleus)
- Spinal trigeminal tract
- Posterior spinocerebellar tract
- Anterolateral pathway
- Location of nucleus ambiguus
- Anterior spinocerebellar tract
- Inferior olivary nucleus
- Pyramid
- Raphe nuclei
- Medial lemniscus
- Medial longitudinal fasciculus (MLF)
- Hypoglossal nucleus
- Hypoglossal nerve fibers
- Internal arcuate fibers
- Fibers of the vagus nerve
- Solitary tract and its nucleus
- Central canal
- What supplies the lateral apsects of the rostral medulla?
- What happens if these vessels are occluded?
- Vessels that supply the lateral rostral medulla:
- VERTEBRAL A.
- posterior inferior cerebellar a. (PICA)
- Occlusion ⇒ lateral medullary syndrome (of Wallenberg)
- What supplies the medial aspect of the rostral medulla?
- What happens if the vessels are occluded?
-
Vessels that supply the medial aspect of rostral medulla:
- anterior spinal a.
- penetrating branches of the VERTEBRAL A.
- also supplies the corticospinal tract (medullary pyramid)
- Occlusion ⇒ medial medullary syndrome
What supplies the lateral aspect of the caudal medulla?
- Vessels that supply the lateral caudal medulla:
- POSTERIOR SPINAL A. (vertebral a.)
What supplies the medial aspect of the caudal medulla?
- Vessels that supply the medial caudal medulla:
- ANTERIOR SPINAL A.
- penetrating branches of the vertebral a.
- also supply the corticospinal tract (medullary pyramid)
- What supplies the lateral aspect of the rostral pons?
- What happens if the vessels are occluded?
- Vessels that supply the lateral rostral pons:
-
SUPERIOR CEREBELLAR A.
- also supplies the middle and superior cerebellar peduncles
- Basilar a. ⇒ short circumferential branches
-
SUPERIOR CEREBELLAR A.
- Occlusion of superior cerebellar a. ⇒ Lateral pontine syndromes