Brainscape Cardiovascular Pharmacology

Question 1

Meds that relieve chest pain: A. Nitrates B. Morphine C. Beta-blockers D. All of the above

Answer 1

A. Nitrates

Question 2

Has side effects such as profound hypotension with rapid IV infusion; lupus-like manifestations such as rashes; arthritis; and positive serum ANA?

Answer 2

Procainamide

Question 3

Drug of choice for prompt relief of chest pain in stable angina

Answer 3

isosorbide dinitrate sublingual

Question 4

Which class of anti-arrhythmic? Na+ Channel Blockers

Answer 4

Class I

Question 5

Which class of anti-arrhythmic? K+ Channel Blockers

Answer 5

Class III

Question 6

Which class of anti-arrhythmic? ? Blockers

Answer 6

Class II

Question 7

Which class of anti-arrhythmic? Ca2+ Channel Blockers

Answer 7

Class IV

Question 8

Which class of Na-channel blockers? Na channel blocking moderate; effect on APD prolong

Answer 8

Class IA

Question 9

Which class of Na-channel blockers? Na channel blocking minimal; effect on APD shorten

Answer 9

Class IB

Question 10

Which class of Na-channel blockers? Na channel blocking marked; effect on APD no effect

Answer 10

Class IC

Question 11

Which class? Quinide

Answer 11

Sub-Class IA

Question 12

Which class? Procainamide

Answer 12

Sub-Class IA

Question 13

Which class? Disopyramide

Answer 13

Sub-Class IA

Question 14

may cause toxicity due to excessive Na+ blockade and slowed conduction showing excessive QT interval prolongation and induction of torsades de pointes; resulting in syncope

Answer 14

Sub-Class IA

Question 15

Which class? Lidocaine

Answer 15

Sub-Class IB

Question 16

for ventricular arrhythmias; especially those associated with myocardial infarction/ischemia

Answer 16

Sub-Class IB

Question 17

Which class? Mexiletine

Answer 17

Sub-Class IB

Question 18

Which class? Phenytoin

Answer 18

Sub-Class IB

Question 19

Which class? Tocainide

Answer 19

Sub-Class IB

Question 20

Flecainide

Answer 20

Sub-Class IC

Question 21

Moricizine

Answer 21

Sub-Class IC

Question 22

Propafenone

Answer 22

Sub-Class IC

Question 23

MOA Beta-blockers?

Answer 23

Decrease automaticity and conduction in slow response cells like the SA node (full of Beta 1 receptor) and the AV node

Question 24

Main target or use for beta blockers?

Answer 24

Ventricular tachycardia and supraventricular tachycardia precipitated by sympathetic stimulation

Question 25

A short-acting ?-blocker used primarily for intraoperative and other acute arrhythmias?

Answer 25

Esmolol

Question 26

A non-selective ?-blocker that prolongs APD; exhibiting class III action; increases ERP

Answer 26

Sotalol

Question 27

Drugs contraindicated in asthma and COPD?

Answer 27

Non-selective beta blockers; Bronchoconstriction occurs because sympathetic nerves innervating the bronchioles normally activate ?2-adrenoceptors that promote bronchodilation

Question 28

Why should beta-blockers be used cautiously in diabetics?

Answer 28

Beta-blockers can also mask the tachycardia that serves as a warning sign for insulin-induced hypoglycemia in diabetic patients

Question 29

Beta-blocker cardiac effect; contractility increase or decrease?

Answer 29

Decrease contractility; negative inotropy

Question 30

Beta-blocker cardiac effect; heart rate increase or decrease?

Answer 30

Decrease

Question 31

Beta-blocker cardiac effect; conduction velocity increase or decrease?

Answer 31

Decrease

Question 32

Beta-blocker cardiac effect; diastolic coronary perfusion time increase or decrease?

Answer 32

Increase

Question 33

Beta-blocker cardiac effect; diastolic ventricular filling time increase or decrease?

Answer 33

Increase

Question 34

Beta-blocker vascular effect; smooth muscle contraction or relaxation?

Answer 34

contraction; mild vasoconstriction

Question 35

Acebutolol B1 selective or non-selective?

Answer 35

?1-selective

Question 36

Carvedilol B1 selective or non-selective?

Answer 36

Non-selective

Question 37

Betaxolol B1 selective or non-selective?

Answer 37

?1-selective

Question 38

Labetalol B1 selective or non-selective?

Answer 38

Non-selective

Question 39

Esmolol B1 selective or non-selective?

Answer 39

?1-selective

Question 40

Nadolol B1 selective or non-selective?

Answer 40

Non-selective

Question 41

nebivolol B1 selective or non-selective?

Answer 41

?1-selective

Question 42

Bisoprolol B1 selective or non-selective?

Answer 42

?1-selective

Question 43

Atenolol B1 selective or non-selective?

Answer 43

?1-selective

Question 44

Penbutolol B1 selective or non-selective?

Answer 44

Non-selective

Question 45

Pindolol B1 selective or non-selective?

Answer 45

Non-selective

Question 46

Propranolol B1 selective or non-selective?

Answer 46

Non-selective

Question 47

Metoprolol B1 selective or non-selective?

Answer 47

?1-selective

Question 48

Sotalol B1 selective or non-selective?

Answer 48

Non-selective

Question 49

Timolol B1 selective or non-selective?

Answer 49

Non-selective

Question 50

Potassium Channel blockers MOA?

Answer 50

blocks K+ channels (or enhances inward current of Na+ channels); prolongs duration of the AP; increases refractoriness (prolonged ERP)

Question 51

Amiodarone class?

Answer 51

Class III K channel blockers

Question 52

Bretylium class?

Answer 52

Class III K channel blockers

Question 53

D-sotalol?

Answer 53

Class III K channel blockers

Question 54

Calcium channel blockers MOA?

Answer 54

Predominantly blocks calcium entry in slow response cells like SA and AV node; causes a slow rise in action potential and prolonged repolarization at the AV node

Question 55

Type of Ca channel blockers that block tachycardias in Ca2+-dependent cells (eg SA; AV node) more selective for heart muscle: DHP or Non-DHP?

Answer 55

Non-DHP

Question 56

Examples of non-dihyropyridines?

Answer 56

Verapamil; Diltiazem

Question 57

Type of Ca channel blockers that only dilate vessels; DO NOT decrease heart rate: DHP or non-DHP?

Answer 57

DHP

Question 58

Examples of dihyropyridines?

Answer 58

Nifedipine; Amlodipine; Felodipine

Question 59

Angina Pharmacology; Effect/s of nitrates: vasodilator; cardiac depressant or both?

Answer 59

Vasodilator

Question 60

Angina Pharmacology; Effect/s of calcium blockers: vasodilator; cardiac depressant or both?

Answer 60

both

Question 61

Angina Pharmacology; Effect/s of beta blockers: vasodilator; cardiac depressant or both?

Answer 61

cardiac depressant

Question 62

Aspirin; clopidogrel; triclopidine and dipyridamole are examples of?

Answer 62

anti-platelets

Question 63

New anti-anginal drug that decreases HR but not BP

Answer 63

Ivabradine