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LU 4 Ther 201 Exam 3 > Brainscape Cardiovascular Pharmacology > Flashcards

Brainscape Cardiovascular Pharmacology Flashcards

1
Q

Meds that relieve chest pain: A. Nitrates B. Morphine C. Beta-blockers D. All of the above

A

A. Nitrates

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2
Q

Has side effects such as profound hypotension with rapid IV infusion; lupus-like manifestations such as rashes; arthritis; and positive serum ANA?

A

Procainamide

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3
Q

Drug of choice for prompt relief of chest pain in stable angina

A

isosorbide dinitrate sublingual

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4
Q

Which class of anti-arrhythmic? Na+ Channel Blockers

A

Class I

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5
Q

Which class of anti-arrhythmic? K+ Channel Blockers

A

Class III

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6
Q

Which class of anti-arrhythmic? ? Blockers

A

Class II

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7
Q

Which class of anti-arrhythmic? Ca2+ Channel Blockers

A

Class IV

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8
Q

Which class of Na-channel blockers? Na channel blocking moderate; effect on APD prolong

A

Class IA

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9
Q

Which class of Na-channel blockers? Na channel blocking minimal; effect on APD shorten

A

Class IB

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10
Q

Which class of Na-channel blockers? Na channel blocking marked; effect on APD no effect

A

Class IC

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11
Q

Which class? Quinide

A

Sub-Class IA

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12
Q

Which class? Procainamide

A

Sub-Class IA

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13
Q

Which class? Disopyramide

A

Sub-Class IA

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14
Q

may cause toxicity due to excessive Na+ blockade and slowed conduction showing excessive QT interval prolongation and induction of torsades de pointes; resulting in syncope

A

Sub-Class IA

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15
Q

Which class? Lidocaine

A

Sub-Class IB

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16
Q

for ventricular arrhythmias; especially those associated with myocardial infarction/ischemia

A

Sub-Class IB

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17
Q

Which class? Mexiletine

A

Sub-Class IB

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18
Q

Which class? Phenytoin

A

Sub-Class IB

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19
Q

Which class? Tocainide

A

Sub-Class IB

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20
Q

Flecainide

A

Sub-Class IC

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21
Q

Moricizine

A

Sub-Class IC

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22
Q

Propafenone

A

Sub-Class IC

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23
Q

MOA Beta-blockers?

A

Decrease automaticity and conduction in slow response cells like the SA node (full of Beta 1 receptor) and the AV node

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24
Q

Main target or use for beta blockers?

A

Ventricular tachycardia and supraventricular tachycardia precipitated by sympathetic stimulation

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25
Q

A short-acting ?-blocker used primarily for intraoperative and other acute arrhythmias?

A

Esmolol

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26
Q

A non-selective ?-blocker that prolongs APD; exhibiting class III action; increases ERP

A

Sotalol

27
Q

Drugs contraindicated in asthma and COPD?

A

Non-selective beta blockers; Bronchoconstriction occurs because sympathetic nerves innervating the bronchioles normally activate ?2-adrenoceptors that promote bronchodilation

28
Q

Why should beta-blockers be used cautiously in diabetics?

A

Beta-blockers can also mask the tachycardia that serves as a warning sign for insulin-induced hypoglycemia in diabetic patients

29
Q

Beta-blocker cardiac effect; contractility increase or decrease?

A

Decrease contractility; negative inotropy

30
Q

Beta-blocker cardiac effect; heart rate increase or decrease?

A

Decrease

31
Q

Beta-blocker cardiac effect; conduction velocity increase or decrease?

A

Decrease

32
Q

Beta-blocker cardiac effect; diastolic coronary perfusion time increase or decrease?

A

Increase

33
Q

Beta-blocker cardiac effect; diastolic ventricular filling time increase or decrease?

A

Increase

34
Q

Beta-blocker vascular effect; smooth muscle contraction or relaxation?

A

contraction; mild vasoconstriction

35
Q

Acebutolol B1 selective or non-selective?

A

?1-selective

36
Q

Carvedilol B1 selective or non-selective?

A

Non-selective

37
Q

Betaxolol B1 selective or non-selective?

A

?1-selective

38
Q

Labetalol B1 selective or non-selective?

A

Non-selective

39
Q

Esmolol B1 selective or non-selective?

A

?1-selective

40
Q

Nadolol B1 selective or non-selective?

A

Non-selective

41
Q

nebivolol B1 selective or non-selective?

A

?1-selective

42
Q

Bisoprolol B1 selective or non-selective?

A

?1-selective

43
Q

Atenolol B1 selective or non-selective?

A

?1-selective

44
Q

Penbutolol B1 selective or non-selective?

A

Non-selective

45
Q

Pindolol B1 selective or non-selective?

A

Non-selective

46
Q

Propranolol B1 selective or non-selective?

A

Non-selective

47
Q

Metoprolol B1 selective or non-selective?

A

?1-selective

48
Q

Sotalol B1 selective or non-selective?

A

Non-selective

49
Q

Timolol B1 selective or non-selective?

A

Non-selective

50
Q

Potassium Channel blockers MOA?

A

blocks K+ channels (or enhances inward current of Na+ channels); prolongs duration of the AP; increases refractoriness (prolonged ERP)

51
Q

Amiodarone class?

A

Class III K channel blockers

52
Q

Bretylium class?

A

Class III K channel blockers

53
Q

D-sotalol?

A

Class III K channel blockers

54
Q

Calcium channel blockers MOA?

A

Predominantly blocks calcium entry in slow response cells like SA and AV node; causes a slow rise in action potential and prolonged repolarization at the AV node

55
Q

Type of Ca channel blockers that block tachycardias in Ca2+-dependent cells (eg SA; AV node) more selective for heart muscle: DHP or Non-DHP?

A

Non-DHP

56
Q

Examples of non-dihyropyridines?

A

Verapamil; Diltiazem

57
Q

Type of Ca channel blockers that only dilate vessels; DO NOT decrease heart rate: DHP or non-DHP?

A

DHP

58
Q

Examples of dihyropyridines?

A

Nifedipine; Amlodipine; Felodipine

59
Q

Angina Pharmacology; Effect/s of nitrates: vasodilator; cardiac depressant or both?

A

Vasodilator

60
Q

Angina Pharmacology; Effect/s of calcium blockers: vasodilator; cardiac depressant or both?

A

both

61
Q

Angina Pharmacology; Effect/s of beta blockers: vasodilator; cardiac depressant or both?

A

cardiac depressant

62
Q

Aspirin; clopidogrel; triclopidine and dipyridamole are examples of?

A

anti-platelets

63
Q

New anti-anginal drug that decreases HR but not BP

A

Ivabradine

LU 4 Ther 201 Exam 3 (2 decks)

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