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LU 4 Ther 201 Exam 3 > Anti-fungals > Flashcards

Anti-fungals Flashcards

1
Q

Drug that has the broadest spectrum among the antifungals

A

Amphotericin B

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2
Q

Polyene Anti-fungal MOA

A

Cell membrane destruction via disruption of osmotic gradient leading to cell death

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3
Q

Azole Anti-fungal MOA

A

Cell membrane destruction via interruption of ergosterol synthesis

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4
Q

Antimetabolites Anti-fungal MOA

A

Inhibitor of both DNA & RNA synthesis via the intra-cytoplasmic conversion of 5-fluocytosine to 5-fluorouracil

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5
Q

Echinocandins Anti-fungal MOA

A

Inhibits peptide in the synthesis of ?(1-3) glucan resulting in disruption of the fungal cell wall and cell death

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6
Q

Allylamine and Morphone Anti-fungal drugs MOA

A

Inhibits different stages of ergosterol synthesis

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7
Q

Amphotericin B Type of Anti-fungal?

A

Polyene

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8
Q

Nystatin Type of Anti-fungal?

A

Polyene

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9
Q

Natamycin Type of Anti-fungal?

A

Polyene

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10
Q

Ketoconazole Type of Anti-fungal?

A

Azole (Imidazole)

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11
Q

Fluconazole Type of Anti-fungal?

A

Azole (Triazole)

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12
Q

Azole of choice in the treatment & secondary prophylaxis of cryptococcal meningitis

A

Fluconazole

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13
Q

Itraconazole Type of Anti-fungal?

A

Azole (Triazole)

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14
Q

Voriconazole Type of Anti-fungal?

A

Azole (Triazole)

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15
Q

Posaconazole Type of Anti-fungal?

A

Azole (Triazole)

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16
Q

Flucytosine Type of Anti-fungal?

A

Anti-metabolite

17
Q

Fungistatic or fungicidal? Amphotericin B

A

Fungicidal

18
Q

Fungistatic or fungicidal? Polyene

A

Fungicidal

19
Q

Fungistatic or fungicidal? Azole

A

Fungistatic

20
Q

Fungistatic or fungicidal? Anti-metabolite

A

Fungistatic

21
Q

Fungistatic or fungicidal? Allylamines

A

Fungistatic

22
Q

Caspofungin Type of Anti-fungal?

A

Echinocandin

23
Q

Micafungin Type of Anti-fungal?

A

Echinocandin

24
Q

Anidulafungin Type of Anti-fungal?

A

Echinocandin

25
Q

Griseofulvin Anti-fungal MOA?

A

Binds to microtubules comprising the spindles and inhibits mitosis

26
Q

Terbinafine Type of Anti-fungal?

A

Allylamine

27
Q

Most specific among all azole in terms of inhibiting fungal cytochrome P450 than human microsomal enzymes

A

Fluconazole

28
Q

Drug of choice for onychomycosis

A

Terbinafine

29
Q

Mucormycosis is an uncommon but severe systemic fungal infection. The drug of choice is:

A

Amphotericin B

30
Q

Clotrimazole and miconazole are topical azoles True or False?

A

TRUE

LU 4 Ther 201 Exam 3 (2 decks)

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