Anti-fungals

Question 1

Drug that has the broadest spectrum among the antifungals

Answer 1

Amphotericin B

Question 2

Polyene Anti-fungal MOA

Answer 2

Cell membrane destruction via disruption of osmotic gradient leading to cell death

Question 3

Azole Anti-fungal MOA

Answer 3

Cell membrane destruction via interruption of ergosterol synthesis

Question 4

Antimetabolites Anti-fungal MOA

Answer 4

Inhibitor of both DNA & RNA synthesis via the intra-cytoplasmic conversion of 5-fluocytosine to 5-fluorouracil

Question 5

Echinocandins Anti-fungal MOA

Answer 5

Inhibits peptide in the synthesis of ?(1-3) glucan resulting in disruption of the fungal cell wall and cell death

Question 6

Allylamine and Morphone Anti-fungal drugs MOA

Answer 6

Inhibits different stages of ergosterol synthesis

Question 7

Amphotericin B Type of Anti-fungal?

Answer 7

Polyene

Question 8

Nystatin Type of Anti-fungal?

Answer 8

Polyene

Question 9

Natamycin Type of Anti-fungal?

Answer 9

Polyene

Question 10

Ketoconazole Type of Anti-fungal?

Answer 10

Azole (Imidazole)

Question 11

Fluconazole Type of Anti-fungal?

Answer 11

Azole (Triazole)

Question 12

Azole of choice in the treatment & secondary prophylaxis of cryptococcal meningitis

Answer 12

Fluconazole

Question 13

Itraconazole Type of Anti-fungal?

Answer 13

Azole (Triazole)

Question 14

Voriconazole Type of Anti-fungal?

Answer 14

Azole (Triazole)

Question 15

Posaconazole Type of Anti-fungal?

Answer 15

Azole (Triazole)

Question 16

Flucytosine Type of Anti-fungal?

Answer 16

Anti-metabolite

Question 17

Fungistatic or fungicidal? Amphotericin B

Answer 17

Fungicidal

Question 18

Fungistatic or fungicidal? Polyene

Answer 18

Fungicidal

Question 19

Fungistatic or fungicidal? Azole

Answer 19

Fungistatic

Question 20

Fungistatic or fungicidal? Anti-metabolite

Answer 20

Fungistatic

Question 21

Fungistatic or fungicidal? Allylamines

Answer 21

Fungistatic

Question 22

Caspofungin Type of Anti-fungal?

Answer 22

Echinocandin

Question 23

Micafungin Type of Anti-fungal?

Answer 23

Echinocandin

Question 24

Anidulafungin Type of Anti-fungal?

Answer 24

Echinocandin

Question 25

Griseofulvin Anti-fungal MOA?

Answer 25

Binds to microtubules comprising the spindles and inhibits mitosis

Question 26

Terbinafine Type of Anti-fungal?

Answer 26

Allylamine

Question 27

Most specific among all azole in terms of inhibiting fungal cytochrome P450 than human microsomal enzymes

Answer 27

Fluconazole

Question 28

Drug of choice for onychomycosis

Answer 28

Terbinafine

Question 29

Mucormycosis is an uncommon but severe systemic fungal infection. The drug of choice is:

Answer 29

Amphotericin B

Question 30

Clotrimazole and miconazole are topical azoles True or False?

Answer 30

TRUE