Brain Tumors and Sex cell tumors Flashcards
Glioblastoma multiforme
Most common in adults
- butterfly glioma
- GFAP
- pseudopalisading pleomorphic tumor cells
meningioma
2nd most common in adults
- from arachnoid cells, benign and resectable
- whorled pattern of spindle cells –> psammoma bodies
Schwannoma
3rd most common in adults
- acoustic scwannoma
- S100 positive
Associated with NF2
oligodendroglioma
frontal lobes
- fried egg cells, round nuclei with clear cytoplasm
pilocytic astrocytoma
most common in children
- GFAP
- rosenthal fibers, eosinophilic corkscrew fibers
medulloblastoma
second most common in children
- homer writhgt rosettes, small blue cells,
- can compress 4th ventricle and cause hydrocephalus
hemangioblastoma
cerebellar
- can produce EPO
- foamy cells
Associated with VHL
dysgerminoma
ovarian germ cell tumor
- malignant
- sheets of uniform cells
- hCG and LDH
Association with Turner syndrome
choriocarcinoma
ovarian germ cell tumor
- malignant
- during or after pregnancy
- no chorionic villi
- spreads to lungs hematogenously
- hCG
Yolk sac
ovarian germ cell tumor
- aggressive malignancy
- yellow friable solid masses
- schiller duval bodies (glomeruli in tumor)
- AFP
teratoma
90% ovarian germ cell tumors
- 2 or 3 germ layers
serous cystadenoma
non germ cell tumor
- bilateral lined with fallopian tube like epithelium
- CA125
serous cystadenocarcinoma
non germ cell tumor
- malignant
- psammoma bodies
- BRCA1,2 and HNPCC risk factors
mucinous cystadenoma
non germ cell tumor
- cyst lined by mucus secreting epithelium, intestine like tissue
mucinous cystadenocarcinoma
non germ cell tumor
- malignant
- pseudomyxoma peritonei –> intracellular accumulation of mucinous material
brenner tumor
non germ cell tumor
- looks like bladder, benign
- appears encapsulated
- coffee bean nuclei on staining
fibromas
non germ cell tumors
- spindle shaped fibroblasts
- Meig’s syndrome –> ovarian fibroma, ascites, hydrothorax
granulosa cell tumor
non germ cell
- precocious puberty –> secretes estrogen
- call-exner bodies –> small follicles with eosinophilic secretions
- abnl uterine bleeding
seminoma (male)
testicular germ cell tumor
- most common, malignant
- fried egg appearance
- increased PLAP
- good prognosis
yolk sac tumor (male)
testicular germ cell tumor
- most common under 3 years
- schiller duval bodies
- increased AFP
choriocarcinoma (male)
testicular germ cell tumor
- disordered syncytiotrophoblastic and cytotrophoblastic elements
- increased hCG
Teratoma (male)
testicular germ cell tumor
- malignant in adults
- increased hCG and/or AFP
embryonal carcinoma (male)
testicular germ cell tumor
- malignant, bad prognosis
- glandular/papillary morphology
- increased hCG and nl AFP
leydig cell (male)
non-germ cell tumor
- reinke crystals
- androgen producing
- gynecomastia in men, precocious pubery in boys
- golden brown color
sertoli cell (male)
non germ cell tumor
- androblastoma from sex cord stroma
testicular lymphoma
non germ cell tumor
- most common testicular CA in older men, metastases to testes and aggressive
