Brain Cancer Staging

Question 1

The histologic classification employed by the WHO for CNS tumors makes use of …?

Answer 1

4 grades.

Question 2

Grade I:

Answer 2

Lesions with low proliferative potential, a frequently discrete nature, and the possibility of cure following surgical resection alone.

1. Juvenile pilocytic astrocytoma.
2. Subependymal giant cell astrocytoma.

Question 3

Grade II:

Answer 3

Lesions that are generally infiltrating and low in mitotic activity but recur. Some tend to progress to higher grades of malignancy.

1. Diffuse astrocytoma.
2. Oligodendroglioma.
3. Oligoastrocytoma.

Question 4

Grade III:

Answer 4

Lesions with histologic evidence of malignancy, generally in the form of mitotic activity, clearly expressed infiltrative capabilities, and anaplasia.

1. Anaplastic astrocytoma.
2. Anaplastic oligoastrocytoma.
3. Anaplastic oligodendroglioma.

Question 5

Grade IV:

Answer 5

Lesions that are mitotically active, necrosis-prone, and generally associated with a rapid pre-op/post-op evolution of disease.

==> Glioblastoma.